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dc.contributor.author
Siniatchkin, Michael
dc.contributor.author
Moehring, Jan
dc.contributor.author
Kroeher, Bianca
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Galka, Andreas
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Ondarza, Gisela von
dc.contributor.author
Moeller, Friederike
dc.contributor.author
Wolff, Stephan
dc.contributor.author
Tagliazucchi, Enzo Rodolfo
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dc.contributor.author
Steinmann, Elisabeth
dc.contributor.author
Boor, Rainer
dc.contributor.author
Stephani, Ulrich
dc.date.available
2020-02-05T20:39:43Z
dc.date.issued
2018-11
dc.identifier.citation
Siniatchkin, Michael; Moehring, Jan; Kroeher, Bianca; Galka, Andreas; Ondarza, Gisela von; et al.; Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study; Elsevier; European Journal Of Paediatric Neurology; 22; 6; 11-2018; 1054-1065
dc.identifier.issn
1090-3798
dc.identifier.uri
http://hdl.handle.net/11336/96785
dc.description.abstract
Objective: Multifocal epileptic activity is an unfavourable feature of a number of epileptic syndromes (Lennox-Gastaut syndrome, West syndrome, severe focal epilepsies) which suggests an overall vulnerability of the brain to pathological synchronization. However, the mechanisms of multifocal activity are insufficiently understood. This explorative study investigates whether pathological connectivity within brain areas of the default mode network as well as thalamus, brainstem and retrosplenial cortex may predispose individuals to multifocal epileptic activity. Methods: 33 children suffering from multifocal and monofocal (control group) epilepsies were investigated using EEG-fMRI recordings during sleep. The blood oxygenated level dependent (BOLD) signal of 15 regions of interest was extracted and temporally correlated (resting-state functional connectivity). Results: Patients with monofocal epilepsies were characterized by strong correlations between the corresponding interhemispheric homotopic regions. This pattern of correlations with pronounced short-distance and weak long-distance functional connectivity resembles the connectivity pattern described for healthy children. Patients with multifocal epileptic activity, however, demonstrated significantly stronger correlations between a large number of regions of the default mode network as well as thalamus and brainstem, with a significant increase in long-distance connectivity compared to children with monofocal epileptic activity. In the group of patients with multifocal epilepsies there were no differences in functional connectivity between patients with or without Lennox-Gastaut syndrome. Conclusion: This explorative study shows that multifocal activity is associated with generally increased long-distance functional connectivity in the brain. It can be suggested that this pronounced connectivity may represent either a risk to pathological over-synchronization or a consequence of the multifocal epileptic activity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
CHILDREN
dc.subject
DEFAULT-MODE NETWORK
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EEG-FMRI
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FUNCTIONAL CONNECTIVITY
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MULTIFOCAL EPILEPSY
dc.subject.classification
Otras Ciencias Físicas
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dc.subject.classification
Ciencias Físicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-01-30T21:57:54Z
dc.journal.volume
22
dc.journal.number
6
dc.journal.pagination
1054-1065
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Siniatchkin, Michael. Christian-Albrechts-Universität zu Kiel; Alemania
dc.description.fil
Fil: Moehring, Jan. Christian-Albrechts-Universität zu Kiel; Alemania
dc.description.fil
Fil: Kroeher, Bianca. Christian-Albrechts-Universität zu Kiel; Alemania
dc.description.fil
Fil: Galka, Andreas. Christian-Albrechts-Universität zu Kiel; Alemania
dc.description.fil
Fil: Ondarza, Gisela von. Christian-Albrechts-Universität zu Kiel; Alemania
dc.description.fil
Fil: Moeller, Friederike. Christian-Albrechts-Universität zu Kiel; Alemania
dc.description.fil
Fil: Wolff, Stephan. Christian-Albrechts-Universität zu Kiel; Alemania
dc.description.fil
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Christian-Albrechts-Universität zu Kiel; Alemania
dc.description.fil
Fil: Steinmann, Elisabeth. Christian-Albrechts-Universität zu Kiel; Alemania
dc.description.fil
Fil: Boor, Rainer. Christian-Albrechts-Universität zu Kiel; Alemania
dc.description.fil
Fil: Stephani, Ulrich. Christian-Albrechts-Universität zu Kiel; Alemania
dc.journal.title
European Journal Of Paediatric Neurology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.ejpn.2018.07.001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1090379817301812
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ejpn-journal.com/article/S1090-3798(17)30181-2/pdf
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