Artículo
Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ
Beccaria, Cristian Gabriel
; Amezcua Vesely, Maria Carolina
; Fiocca Vernengo, Facundo
; Gehrau, Ricardo Carlos
; Ramello, María Cecilia
; Tosello Boari, Jimena
; Gorosito Serran, Melisa
; Mucci, Juan Sebastián
; Piaggio, Eliane; Campetella, Oscar Eduardo
; Acosta Rodriguez, Eva Virginia
; Montes, Carolina Lucia
; Gruppi, Adriana
Fecha de publicación:
12/2018
Editorial:
Nature Publishing Group
Revista:
Nature Communications
ISSN:
2041-1723
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Germinal centers (GC) are important sites for high-affinity and long-lived antibody induction. Tight regulation of GC responses is critical for maintaining self-tolerance. Here, we show that Galectin-3 (Gal-3) is involved in GC development. Compared with WT mice, Gal-3 KO mice have more GC B cells and T follicular helper cells, increased percentages of antibody-secreting cells and higher concentrations of immunoglobulins and IFN-γ in serum, and develop a lupus-like disease. IFN-γ blockade in Gal-3 KO mice reduces spontaneous GC formation, class-switch recombination, autoantibody production and renal pathology, demonstrating that IFN-γ overproduction sustains autoimmunity. The results from chimeric mice show that intrinsic Gal-3 signaling in B cells controls spontaneous GC formation. Taken together, our data provide evidence that Gal-3 acts directly on B cells to regulate GC responses via IFN-γ and implicate the potential of Gal-3 as a therapeutic target in autoimmunity.
Palabras clave:
GALECTIN-3
,
B-CELL
,
LUPUS-LIKE
,
GERMINAL CENTERS
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos(IIB-INTECH)
Articulos de INST.DE INVEST.BIOTECNOLOGICAS - INSTITUTO TECNOLOGICO CHASCOMUS
Articulos de INST.DE INVEST.BIOTECNOLOGICAS - INSTITUTO TECNOLOGICO CHASCOMUS
Citación
Beccaria, Cristian Gabriel; Amezcua Vesely, Maria Carolina; Fiocca Vernengo, Facundo; Gehrau, Ricardo Carlos; Ramello, María Cecilia; et al.; Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ; Nature Publishing Group; Nature Communications; 9; 1; 12-2018; 1-15
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