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dc.contributor.author
Casciano, R.  
dc.contributor.author
Malangone, Elisabetta  
dc.contributor.author
Ramachandran, A.  
dc.contributor.author
Gagliardino, Juan Jose  
dc.date.available
2020-02-04T15:01:10Z  
dc.date.issued
2011-04  
dc.identifier.citation
Casciano, R.; Malangone, Elisabetta; Ramachandran, A.; Gagliardino, Juan Jose; A quantitative assessment of patient barriers to insulin; Wiley Blackwell Publishing, Inc; International Journal of Clinical Practice; 65; 4; 4-2011; 408-414  
dc.identifier.issn
1742-1241  
dc.identifier.uri
http://hdl.handle.net/11336/96673  
dc.description.abstract
Aim: To assess diabetes treatment preferences with a focus on patient barriers to insulin treatment. Materials and Methods: A questionnaire using indirect and direct methods was administered as part of the International Diabetes Management Practices Study (IDMPS). Discrete choice modelling was used to assess how product attributes influence patients' preferences for diabetes treatment. A multinomial logit model was used to find the odds ratio for each parameter, representing the probability of selecting a chosen alternative given a choice set. This allowed for the derivation of relative attribute importance, an indication of how influential product attributes are in the respondents' choices. Results: The IDMPS questionnaire was administered to 14,033 individuals with diabetes in 18 countries. The majority of respondents were women (53%) and had Type 2 diabetes mellitus (T2DM; 85%). Across subgroups, administration (i.e. oral vs. injection) was a driver of preference. Patient preferences varied according to diabetes type; individuals with T2DM assigned much higher relative importance to administration than those with Type 1 diabetes mellitus (T1DM; 30.86% vs. 4.99%; p < 0.0001). Individuals with T2DM treated with insulin placed less importance on administration than insulin-naïve T2DM patients (3.09% vs. 47.48%; p < 0.0001). Diabetes education also had a significant effect on the priority given to administration between T2DM patients who received diabetes training and those who did not (28.21% vs. 33.68%, respectively; p < 0.0001). Conclusion: The insulin barriers perceived by patients with diabetes evolved with their disease experience. While administration was the primary preference driver for insulin-naïve patients, patients were increasingly concerned with more clinically relevant barriers as they gained experience with insulin. This finding suggests that patients using insulin understand the importance of achieving an optimal balance between safety and efficacy.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley Blackwell Publishing, Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
diabetes  
dc.subject
insulin treatment  
dc.subject
patient barriers  
dc.subject.classification
Endocrinología y Metabolismo  
dc.subject.classification
Medicina Clínica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
A quantitative assessment of patient barriers to insulin  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-11-25T18:39:38Z  
dc.identifier.eissn
1368-5031  
dc.journal.volume
65  
dc.journal.number
4  
dc.journal.pagination
408-414  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Casciano, R.. Analytica International; Estados Unidos  
dc.description.fil
Fil: Malangone, Elisabetta. Analytica International; Estados Unidos  
dc.description.fil
Fil: Ramachandran, A.. Dr. A. Ramachandran’s Diabetes Hospitals; India  
dc.description.fil
Fil: Gagliardino, Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Endocrinología Experimental y Aplicada (i); Argentina  
dc.journal.title
International Journal of Clinical Practice  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1742-1241.2010.02590.x  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1742