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dc.contributor.author
De Queiroz, Alvaro A.A.
dc.contributor.author
França, Écio J.
dc.contributor.author
Abraham, Gustavo Abel
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dc.contributor.author
Roman, Julio San
dc.date.available
2020-02-04T14:06:53Z
dc.date.issued
2004-08
dc.identifier.citation
De Queiroz, Alvaro A.A.; França, Écio J.; Abraham, Gustavo Abel; Roman, Julio San; Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers; John Wiley & Sons Inc; Journal of Applied Polymer Science; 93; 3; 8-2004; 1337-1347
dc.identifier.issn
0021-8995
dc.identifier.uri
http://hdl.handle.net/11336/96666
dc.description.abstract
Solid dispersions of the nonsteriodal antiin-flammatory drug (NSAID) 2′,4′-difluoro-4-hydroxy-(1,1′-biphenyl)-3-carboxylic acid (DIF) with the water-soluble random copolymer poly(N-vinyl-2-pyrrolidone-co-N, N′-dimethylacrylamide) (VP-co-DMAm) were prepared by the solvent method (coevaporates) and melting DIP/VP-co-DMAm (cofused) physical mixtures. Differential scanning calorimetry (DSC), infrared spectroscopy (FTIR), and X-ray diffraction (XRD) were used to elucidate the possible interaction between the NSAID drug and VP-co-DMAm in cofused and coevaporated polymer-drug solid dispersions. The XRD and FTIR studies suggest the presence of physical interactions with formation of a charge transfer complex between DIF and the VP-co-DMAm copolymers as a consequence of the coevaporation or cofusion processes. In solution, dynamic and equilibrium solubility studies were determined to elucidate the mechanism of interaction between DIP and VP-co-DMAm copolymers. Thermodynamics data about the DIP: VP-co-DMAm dissolution process indicate that the coevaporated systems are more stable that the cofused systems. The dissolution of the cofused and coevaporated systems was diffusion controlled and the dissolution kinetics followed the Noyes-Whitney and the Levich equations. Molecular simulations using semiempirical quantum chemical calculations reinforce the experimental results, suggesting that the improvement in the DIF solubility could be attributed to the charge transfer complex formation between the drug and VP-co-DMAm copolymers.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHARGE TRANSFER
dc.subject
DIFFUSION
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DISPERSIONS
dc.subject.classification
Ingeniería de los Materiales
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dc.subject.classification
Ingeniería de los Materiales
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-01-30T14:58:19Z
dc.journal.volume
93
dc.journal.number
3
dc.journal.pagination
1337-1347
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
New York
dc.description.fil
Fil: De Queiroz, Alvaro A.A.. Universidade Federal de Itajubá; Brasil
dc.description.fil
Fil: França, Écio J.. Universidade Federal de Itajubá; Brasil
dc.description.fil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.description.fil
Fil: Roman, Julio San. Instituto en Ciencia y Tecnología de Polímeros; España
dc.journal.title
Journal of Applied Polymer Science
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/app.20552
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/app.20552
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