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dc.contributor.author
Straminsky, Samanta
dc.contributor.author
Itkin, Boris
dc.contributor.author
De Ronato, Gabriela
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Bibbó, Florencia
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Lewi, Daniel
dc.contributor.author
García, Gabriela
dc.contributor.author
Bardach, Ariel Esteban
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dc.date.available
2020-02-03T21:22:58Z
dc.date.issued
2018-11
dc.identifier.citation
Straminsky, Samanta; Itkin, Boris; De Ronato, Gabriela; Bibbó, Florencia; Lewi, Daniel; et al.; Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study; Medwin Publishers; Open Access Journal of Cancer & Oncology; 2; 4; 11-2018; 134-137
dc.identifier.issn
2578-4625
dc.identifier.uri
http://hdl.handle.net/11336/96639
dc.description.abstract
Background: The addition of adjuvant chemotherapy (ACT) to the surgical treatment of locally advanced colon cancer (CC) was shown to reduce relapses in stage III disease, although it remains controversial in stage II. However, an underutilization of ACT in stage III patients was reported. Data on use of ACT in stage II and in older patients in the ?real world? in developing countries are limited. We aimed to describe management and outcome of non-metastatic colon cancer patients in a community hospital in Argentina.Methods: We retrospectively reviewed clinical charts of 99 patients with non-metastatic CC admitted in our Department between 2007 and 2016 extracting data on surgical treatment and chemotherapy use.Results: Emergency surgery was performed in 36.2% of cases. Near 72% of patients had 12 or more lymph nodes examined. Adjuvant chemotherapy was delivered to 93.1% of patients with stage III, to 38.1% of patients with stage II disease, and to 94.1% of stage III patients older than 70 years. Ninety six percent of patients with stage III disease received oxaliplatin-based chemotherapy. Similar proportions (near 50%) of patients <70 and > 70 years completed chemotherapy. After the median follow up of 2.1 years, (Interquartile range, 1.4 to 4.4 years), 16.2% of patients had a relapse.Conclusion: A guideline-compliant lymphadenectomy and ACT were performed in the majority of patients with CC in the routine practice in a developing country. The proportion of emergency surgical interventions is high. High proportion of older patients received ACT, and its completion rate in this subgroup is similar to younger patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Medwin Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
NON-METASTATIC COLON CANCER
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ADJUVANT CHEMOTHERAPY
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ELDERLY PATIENTS
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REAL-WORLD EVIDENCE
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Oncología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-01-31T19:01:15Z
dc.journal.volume
2
dc.journal.number
4
dc.journal.pagination
134-137
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Straminsky, Samanta. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
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Fil: Itkin, Boris. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
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Fil: De Ronato, Gabriela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
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Fil: Bibbó, Florencia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
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Fil: Lewi, Daniel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
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Fil: García, Gabriela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
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Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
dc.journal.title
Open Access Journal of Cancer & Oncology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://medwinpublishers.com/OAJCO/OAJCO16000134.pdf
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.23880/oajco-16000134
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