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dc.contributor.author
Toni, Nicolas
dc.contributor.author
Schinder, Alejandro Fabian
dc.date.available
2016-12-16T21:16:48Z
dc.date.issued
2015-12
dc.identifier.citation
Toni, Nicolas; Schinder, Alejandro Fabian; Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus; Cold Spring Harbor Laboratory Press; Cold Spring Harbor Perspectives in Biology; 8; 1; 12-2015
dc.identifier.issn
1943-0264
dc.identifier.uri
http://hdl.handle.net/11336/9656
dc.description.abstract
The adult hippocampus generates functional dentate granule cells (GCs) that release glutamate onto target cells in the hilus and cornus ammonis (CA)3 region, and receive glutamatergic and γ-aminobutyric acid (GABA)ergic inputs that tightly control their spiking activity. The slow and sequential development of their excitatory and inhibitory inputs makes them particularly relevant for information processing. Although they are still immature, new neurons are recruited by afferent activity and display increased excitability, enhanced activity-dependent plasticity of their input and output connections, and a high rate of synaptogenesis. Once fully mature, new GCs show all the hallmarks of neurons generated during development. In this review, we focus on how developing neurons remodel the adult dentate gyrus and discuss key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cold Spring Harbor Laboratory Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Neurogenesis
dc.subject
Granule Cells
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Functional Integration
dc.subject
Structural Studies
dc.subject.classification
Otras Ciencias Médicas
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Otras Ciencias Médicas
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-16T17:27:36Z
dc.journal.volume
8
dc.journal.number
1
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Toni, Nicolas. Universite de Lausanne; Suiza
dc.description.fil
Fil: Schinder, Alejandro Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
dc.journal.title
Cold Spring Harbor Perspectives in Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://cshperspectives.cshlp.org/content/8/1/a018903
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1101/cshperspect.a018903