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dc.contributor.author
González, C.
dc.contributor.author
Moreno, Laura Susana
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Fumuso, Elida Ana
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García, J.
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Rivulgo, Virginia Margarita
dc.contributor.author
Confalonieri, Alejandra
dc.contributor.author
Sparo, Mónica Delfina
dc.contributor.author
Sanchez Bruni, Sergio Fabian
dc.date.available
2020-02-03T17:59:53Z
dc.date.issued
2010-06
dc.identifier.citation
González, C.; Moreno, Laura Susana; Fumuso, Elida Ana; García, J.; Rivulgo, Virginia Margarita; et al.; Enrofloxacin-based therapeutic strategy for the prevention of endometritis in susceptible mares; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 33; 3; 6-2010; 287-294
dc.identifier.issn
0140-7783
dc.identifier.uri
http://hdl.handle.net/11336/96545
dc.description.abstract
Enrofloxacin (EFX) is often used empirically to prevent uterine infections in mares in order to improve efficiency on Commercial Embryo Transfer Farms. This study investigated the uterine distribution of EFX and its metabolite ciprofloxacin (CFX) in mares and assessed the minimal inhibitory concentrations (MIC) of EFX against various common pathogens as a basis for establishing a rational dosing schedule. Plasma and uterine pharmacokinetic (PK) studies were performed in two groups (n = 5) of healthy mares following intravenous (i.v.) administration of EFX at either 2.5 and at 5 mg/kg bodyweight. Plasma and endometrial tissue samples, taken before for up to 48 h after treatment were analysed by Reverse Phase HPLC. MIC values for wild strains of Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive bacteria (β-haemolytic streptococci) ranged from 0.25-2 and 1.5-3.0 μg/mL respectively. In terms of tissue distribution, the sum of the endometrial concentrations of the parent drug (EFX) and its active metabolite (CFX) (in terms of AUC), exceeded those in plasma by 249% and 941% following administration of EFX at 2.5 and 5 mg/kg respectively. After i.v. treatment with EFX at 5 mg/kg, endometrial concentrations of EFX and CFX above the MIC value were detected for 36-48 and 22-43 h posttreatment for Gram-negative and -positive isolates respectively. Concentrations above MIC were maintained for much shorter periods at the lower (2.5 mg/kg) treatment dose. Based on these results, a conventional dose (5 mg/kg) of EFX given prebreeding followed by two further doses at 36-48 h postbreeding are proposed as a rational strategy for using of EFX as a preventative therapy against a variety of common bacterial strains associated with equine endometritis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Enrofloxacin
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Endometritis
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Horses
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Pharmacokinetics
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Otras Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Enrofloxacin-based therapeutic strategy for the prevention of endometritis in susceptible mares
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-24T17:38:14Z
dc.journal.volume
33
dc.journal.number
3
dc.journal.pagination
287-294
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: González, C. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
dc.description.fil
Fil: Moreno, L.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Fumuso, E..
dc.description.fil
Fil: García, J..
dc.description.fil
Fil: Rivulgo, M..
dc.description.fil
Fil: Confalonieri, A..
dc.description.fil
Fil: Sparo, M..
dc.description.fil
Fil: Sánchez Bruni, S..
dc.journal.title
Journal of Veterinary Pharmacology and Therapeutics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2885.2009.01135.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1111/j.1365-2885.2009.01135.x
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