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dc.contributor.author
Ruiz, Paul
dc.contributor.author
Calliari, Aldo
dc.contributor.author
Pautassi, Ricardo Marcos
dc.date.available
2020-02-01T02:31:13Z
dc.date.issued
2018-08
dc.identifier.citation
Ruiz, Paul; Calliari, Aldo; Pautassi, Ricardo Marcos; Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption; Elsevier Science; Behavioural Brain Research; 348; 8-2018; 160-170
dc.identifier.issn
0166-4328
dc.identifier.uri
http://hdl.handle.net/11336/96467
dc.description.abstract
Depression usually emerges during adolescence, is significantly more frequent in women, and exhibits comorbidity with alcohol (ethanol) use disorders. Most of the pre-clinical studies assessing the link between depression and ethanol intake, however, have employed only males or relied on stress-induced depression, or induced the experimentally-induced, depressive-like phenotype, during adolescence yet measured ethanol intake at adulthood. This study assessed, in Wistar male and female adolescent rats, the effects of inducing experimental depression (via administration of 1.0 mg/kg reserpine [RES], a monoamine depleting drug, between postnatal day [PD] 30 to PD33) on the acquisition of voluntary ethanol drinking during PD38 to PD42), and the modulation of these effects by fluoxetine (FLUOX, 10.0 mg/kg) on PDs 34–37. RES-treated rats exhibited a significant reduction of dopamine levels at the insula, no significant changes in circulating levels of thyroxine T4, and reduced distance travelled in an open field. Repeated treatment with RES heightened ethanol intake in female, but not in male, rats; and effect that was inhibited by FLUOX. Similarly, RES significantly increased, and FLUOX reversed, risk-taking behaviors in a concentric square field (CSF) test. FLUOX significantly increased shelter-seeking in the CSF and reduced insular dopamine levels. These results indicate that depression, in females, can kindle the initiation of voluntary ethanol drinking in adolescence (one of the most reliable predictors of being diagnosed with an AUD), and pinpoint alterations in risk-taking as potential mechanisms underlying this effect. Adolescent women afflicted by mood disorders should be specifically targeted for interventions directed towards delaying initiation of alcohol consumption.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ETHANOL
dc.subject
EXPERIMENTAL DEPRESSION
dc.subject
FLUOXETINE, ADOLESCENTS
dc.subject
RESERPINE
dc.subject.classification
Drogadicción
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-23T14:26:16Z
dc.journal.volume
348
dc.journal.pagination
160-170
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Ruiz, Paul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad de la República; Uruguay
dc.description.fil
Fil: Calliari, Aldo. Universidad de la República; Uruguay
dc.description.fil
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.journal.title
Behavioural Brain Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbr.2018.04.011
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432818302821
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