Artículo
Effects of contrasting demographic histories on selection at major histocompatibility complex loci in two sympatric species of tuco-tucos (Rodentia: Ctenomyidae)
Fecha de publicación:
02/2010
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Biological Journal of The Linnean Society
ISSN:
0024-4066
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Resumen
To explore the impact of history on selection and genetic structure at functional loci, we compared patterns of major histocompatibility complex (MHC) variability in two sympatric species of ctenomyid rodents with different demographic backgrounds. Although Ctenomys talarum has experienced a stable demographic history, Ctenomys australis has undergone a recent demographic expansion. Accordingly, we predicted that MHC allele frequency distributions should be more skewed, differences between coding and noncoding regions should be less pronounced, and evidence of current selection on MHC loci should be reduced in C. australis relative to C. talarum. To test these predictions, we compared variation at the MHC class II DRB and DQA genes with that at multiple neutral markers, including DQA intron 2, the mitochondrial control region, and 8–12 microsatellite loci. These analyses supported the first two of our predictions but indicated that estimates of selection (based on ω-values) were greater for C. australis. Further exploration of these data, however, revealed differences in the time frames over which selection appears to have acted on each species, with evidence of contemporary selection on MHC loci being limited to C. talarum. Collectively, these findings indicate that demographic history can substantially influence genetic structure at functional loci and that the effects of history on selection may be temporally complex and dynamic.
Palabras clave:
CTENOMYS AUSTRALIS
,
CTENOMYS TALARUM
,
EXPANSION
,
POPULATION
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IIMYC)
Articulos de INSTITUTO DE INVESTIGACIONES MARINAS Y COSTERAS
Articulos de INSTITUTO DE INVESTIGACIONES MARINAS Y COSTERAS
Citación
Cutrera, Ana Paula; Lacey, Eileen Anne; Mora, Matias Sebastian; Lessa, Enrique P.; Effects of contrasting demographic histories on selection at major histocompatibility complex loci in two sympatric species of tuco-tucos (Rodentia: Ctenomyidae); Wiley Blackwell Publishing, Inc; Biological Journal of The Linnean Society; 99; 2; 2-2010; 260-277
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