Mostrar el registro sencillo del ítem
dc.contributor.author
Simón, Layla Yamila
dc.contributor.author
Saez Lancellotti, Tania Emilce Estefania
dc.contributor.author
Cortese, Leandro Gastón
dc.contributor.author
Veisaga, María Luisa
dc.contributor.author
Chantarasinlapin, Preaw
dc.contributor.author
Barbieri, Alejandro
dc.contributor.author
Fornes, Miguel Walter
dc.date.available
2020-01-30T23:11:28Z
dc.date.issued
2018-08
dc.identifier.citation
Simón, Layla Yamila; Saez Lancellotti, Tania Emilce Estefania; Cortese, Leandro Gastón; Veisaga, María Luisa; Chantarasinlapin, Preaw; et al.; Olive oil addition to the high-fat diet reduces methylglyoxal (MG-H1) levels increased in hypercholesterolemic rabbits; IOS Press; Mediterranean Journal of Nutrition and Metabolism; 12; 1; 8-2018; 13-21
dc.identifier.issn
1973-7998
dc.identifier.uri
http://hdl.handle.net/11336/96344
dc.description.abstract
Methylglyoxal (MG) is a highly reactive compound derived from sugar metabolism, precursor of cytotoxic products named Advanced Glycation End products (AGEs). Increased MG levels and MG-related AGEs have been long associated with diabetes and its complications. The association between MG and hypercholesterolemia -induced by high-fat diets- has not been studied previously, neither the effect of olive oil addition to this diets. OBJECTIVE: To analyze the variations of MG and cholesterol levels under the effect of high-fat and olive oil-enriched diets. METHODS: Sixteen healthy male adult (New Zealand White, 6 months old) rabbits were fed with commercial pellets (control, four rabbits), or with 14% of bovine grease added to the pellets (high-fat diet, twelve rabbits). After six months, bovine grease was reduced to 7% (half fat diet, eight rabbits). Then, 7% of olive oil was added to the pellets (protective diet, four rabbits). Glycaemia, cholesterolemia, HDL-cholesterolemia, triglyceridemia, fructosamine and MG-H1 levels were assessed in all experimental conditions (n = 4). RESULTS: The high-fat diet promoted a hypercholesterolemia associated with increased MG-H1 levels (p > 0.05) in nondiabetic and non-obese rabbits. Replacement of the high-fat diet with olive oil decreased significantly the cholesterolemia and MG-H1 levels (p > 0.05). CONCLUSIONS:Our data indicates that the replacement of a high-fat diet with olive oil can recover normal blood cholesterol values and can decrease MG-H1 levels.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
IOS Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HIGH-FAT DIET
dc.subject
HYPERCHOLESTEROLEMIA
dc.subject
METHYLGLYOXAL
dc.subject
OLIVE OIL
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Olive oil addition to the high-fat diet reduces methylglyoxal (MG-H1) levels increased in hypercholesterolemic rabbits
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-21T20:07:20Z
dc.journal.volume
12
dc.journal.number
1
dc.journal.pagination
13-21
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Clifton
dc.description.fil
Fil: Simon, Layla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Saez Lancellotti, Tania Emilce Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Cortese, Leandro. Universidad Nacional de Cuyo; Argentina
dc.description.fil
Fil: Veisaga, María Luisa. Fairchild Tropical Botanic Garden; . Florida International University; Estados Unidos
dc.description.fil
Fil: Chantarasinlapin, Preaw. Florida International University; Estados Unidos. Robert Stempel College Of Public Health And Social Work; . International University;
dc.description.fil
Fil: Barbieri, Alejandro. Florida International University; Estados Unidos
dc.description.fil
Fil: Fornes Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.journal.title
Mediterranean Journal of Nutrition and Metabolism
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3233/MNM-180229
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://content.iospress.com/articles/mediterranean-journal-of-nutrition-and-metabolism/mnm180229
Archivos asociados