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dc.contributor.author
Sui, Jianhua
dc.contributor.author
Hwang, William C.
dc.contributor.author
Perez, Sandra
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dc.contributor.author
Wei, Ge
dc.contributor.author
Aird, Daniel
dc.contributor.author
Chen, Li-Mei
dc.contributor.author
Santelli, Eugenio
dc.contributor.author
Stec, Boguslaw
dc.contributor.author
Cadwell, Greg
dc.contributor.author
Ali, Maryam
dc.contributor.author
Wan, Hongquan
dc.contributor.author
Murakami, Akikazu
dc.contributor.author
Yammanuru, Anuradha
dc.contributor.author
Han, Thomas
dc.contributor.author
Cox, Nancy J.
dc.contributor.author
Bankston, Laurie A.
dc.contributor.author
Donis, Ruben O.
dc.contributor.author
Liddington, Robert C.
dc.contributor.author
Marasco, Wayne A.
dc.date.available
2020-01-30T18:26:18Z
dc.date.issued
2009-03
dc.identifier.citation
Sui, Jianhua; Hwang, William C.; Perez, Sandra; Wei, Ge; Aird, Daniel; et al.; Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses; Nature Publishing Group; Nature Structural and Molecular Biology; 16; 3; 3-2009; 265-273
dc.identifier.issn
1072-8368
dc.identifier.uri
http://hdl.handle.net/11336/96252
dc.description.abstract
Influenza virus remains a serious health threat, owing to its ability to evade immune surveillance through rapid genetic drift and reassortment. Here we used a human non-immune antibody phage-display library and the H5 hemagglutinin ectodomain to select ten neutralizing antibodies (nAbs) that were effective against all group 1 influenza viruses tested, including H5N1 'bird flu' and the H1N1 'Spanish flu'. The crystal structure of one such nAb bound to H5 shows that it blocks infection by inserting its heavy chain into a conserved pocket in the stem region, thus preventing membrane fusion. Nine of the nAbs employ the germline gene VH1-69, and all seem to use the same neutralizing mechanism. Our data further suggest that this region is recalcitrant to neutralization escape and that nAb-based immunotherapy is a promising strategy for broad-spectrum protection against seasonal and pandemic influenza viruses.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
INFLUENZA
dc.subject
MONOCLONAL ANTIBODIES
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IMMUNOTHERAPY
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H5N1
dc.subject.classification
Otras Biotecnologías de la Salud
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dc.subject.classification
Biotecnología de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-11-08T15:14:51Z
dc.identifier.eissn
1545-9985
dc.journal.volume
16
dc.journal.number
3
dc.journal.pagination
265-273
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Sui, Jianhua. Harvard Medical School; Estados Unidos. Dana-farber Cancer Institute; Estados Unidos
dc.description.fil
Fil: Hwang, William C.. Sanford Burnham Prebys Medical Discovery Institute; Estados Unidos
dc.description.fil
Fil: Perez, Sandra. National Center For Immunization And Respiratory Diseases; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Wei, Ge. Sanford Burnham Prebys Medical Discovery Institute; Estados Unidos
dc.description.fil
Fil: Aird, Daniel. Harvard Medical School; Estados Unidos. Dana-farber Cancer Institute; Estados Unidos
dc.description.fil
Fil: Chen, Li-Mei. National Center For Immunization And Respiratory Diseases; Estados Unidos
dc.description.fil
Fil: Santelli, Eugenio. Sanford Burnham Prebys Medical Discovery Institute; Estados Unidos
dc.description.fil
Fil: Stec, Boguslaw. Sanford Burnham Prebys Medical Discovery Institute; Estados Unidos
dc.description.fil
Fil: Cadwell, Greg. Sanford Burnham Prebys Medical Discovery Institute; Estados Unidos
dc.description.fil
Fil: Ali, Maryam. Dana-farber Cancer Institute; Estados Unidos. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Wan, Hongquan. National Center For Immunization And Respiratory Diseases; Estados Unidos
dc.description.fil
Fil: Murakami, Akikazu. Harvard Medical School; Estados Unidos. Dana-farber Cancer Institute; Estados Unidos
dc.description.fil
Fil: Yammanuru, Anuradha. Dana-farber Cancer Institute; Estados Unidos. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Han, Thomas. Harvard Medical School; Estados Unidos. Dana-farber Cancer Institute; Estados Unidos
dc.description.fil
Fil: Cox, Nancy J.. National Center For Immunization And Respiratory Diseases; Estados Unidos
dc.description.fil
Fil: Bankston, Laurie A.. Sanford Burnham Prebys Medical Discovery Institute; Estados Unidos
dc.description.fil
Fil: Donis, Ruben O.. National Center For Immunization And Respiratory Diseases; Estados Unidos
dc.description.fil
Fil: Liddington, Robert C.. Sanford Burnham Prebys Medical Discovery Institute; Estados Unidos
dc.description.fil
Fil: Marasco, Wayne A.. Dana-farber Cancer Institute; Estados Unidos. Harvard Medical School; Estados Unidos
dc.journal.title
Nature Structural and Molecular Biology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/nsmb.1566
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nsmb.1566
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692245/
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