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dc.contributor.author
Bekinschtein, Pedro Alejandro
dc.contributor.author
Kent, Brianne A.
dc.contributor.author
Oomen, Charlotte A.
dc.contributor.author
Clemenson, Gregory D.
dc.contributor.author
Gage, Fred H.
dc.contributor.author
Saksida, Lisa M.
dc.contributor.author
Bussey, Timothy J.
dc.date.available
2020-01-30T17:27:14Z
dc.date.issued
2013-11
dc.identifier.citation
Bekinschtein, Pedro Alejandro; Kent, Brianne A.; Oomen, Charlotte A.; Clemenson, Gregory D.; Gage, Fred H.; et al.; BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories; Cell Press; Cell Reports; 5; 3; 11-2013; 759-768
dc.identifier.issn
2211-1247
dc.identifier.uri
http://hdl.handle.net/11336/96233
dc.description.abstract
Successful memory involves not only remembering information over time, but also keeping memories distinct and less confusable. The computational process for making representations for similar input patterns more distinct from each other has been referred to as “pattern separation.” In this work, we developed a set of behavioral conditions that allowed us to manipulate the load for pattern separation at different stages of memory. Thus, we provide experimental evidence that a brain-derived neurotrophic factor (BDNF)-dependent pattern separation process occurs during the encoding/storage/consolidation, but not the retrieval stage of memory processing. We also found that a spontaneous increase in BDNF in the dentate gyrus of the hippocampus is associated with exposure to landmarks delineating similar, but not dissimilar, spatial locations, suggesting that BDNF is expressed on an “as-needed” basis for pattern separation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
PATTERN SEPARATION
dc.subject
BDNF
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MEMORY CONSOLIDATION
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DENTATE GYRUS
dc.subject.classification
Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-01-10T14:53:44Z
dc.journal.volume
5
dc.journal.number
3
dc.journal.pagination
759-768
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Boston
dc.description.fil
Fil: Bekinschtein, Pedro Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Cambridge; Reino Unido. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina
dc.description.fil
Fil: Kent, Brianne A.. University of Cambridge; Reino Unido
dc.description.fil
Fil: Oomen, Charlotte A.. University of Cambridge; Reino Unido
dc.description.fil
Fil: Clemenson, Gregory D.. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil
Fil: Gage, Fred H.. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil
Fil: Saksida, Lisa M.. University of Cambridge; Reino Unido
dc.description.fil
Fil: Bussey, Timothy J.. University of Cambridge; Reino Unido
dc.journal.title
Cell Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.cell.com/cell-reports/fulltext/S2211-1247%2813%2900550-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.celrep.2013.09.027
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