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Artículo

Human apolipoprotein A-I Gly26Arg stimulation of inflammatory responses via NF-kB activation: Potential roles in amyloidosis?

Ramella, NahuelIcon ; Andújar, Isabel; Ríos, José Luis; Rosu, Silvana AntoniaIcon ; Tricerri, Maria AlejandraIcon ; Schinella, Guillermo Raúl
Fecha de publicación: 12/2018
Editorial: Elsevier
Revista: Pathophysiology (amsterdam)
ISSN: 0928-4680
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

The cascade of molecular events leading to Human apolipoprotein A–I (apoA–I) amyloidosis is not completely understood, not even the pathways that determine clinical manifestations associated to systemic protein deposition in organs such as liver, kidney and heart. About twenty natural variants of apoA–I were described as inducing amyloidosis, but the mechanisms driving their aggregation and deposition are still unclear. We previously identified that the mutant Gly26Arg but not Lys107-0 induced the release of cytokines and reactive oxygen species from cultured RAW 264.7 murine macrophages, suggesting that part of the pathogenic pathway could elicit of an inflammatory signal. In this work we gained deep insight into this mechanism and determined that Gly26Arg induced a specific pro-inflammatory cascade involving activation of NF-κB and its translocation into the nucleus. These findings suggest that some but not all apoA–I natural variants might promote a pro-oxidant microenvironment which could in turn result in oxidative processing of the variants into a misfolded conformation.
Palabras clave: AMYLOIDOSIS , APOLIPOPROTEIN A-I VARIANTS , INFLAMMATION , MACROPHAGES ACTIVATION , NUCLEAR FACTOR-ΚB
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/96201
URL: https://www.sciencedirect.com/science/article/pii/S0928468018300993
DOI: http://dx.doi.org/10.1016/j.pathophys.2018.08.002
Colecciones
Articulos(INIBIOLP)
Articulos de INST.DE INVEST.BIOQUIMICAS DE LA PLATA
Citación
Ramella, Nahuel; Andújar, Isabel; Ríos, José Luis; Rosu, Silvana Antonia; Tricerri, Maria Alejandra; et al.; Human apolipoprotein A-I Gly26Arg stimulation of inflammatory responses via NF-kB activation: Potential roles in amyloidosis?; Elsevier; Pathophysiology (amsterdam); 25; 4; 12-2018; 397-404
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