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dc.contributor.author
Lallemend, Francois
dc.contributor.author
Sterzenbach, Ulrich
dc.contributor.author
Hadjab Lallemend, Saida
dc.contributor.author
Aquino, Jorge Benjamin
dc.contributor.author
Castelo Branco, Goncalo
dc.contributor.author
Sinha, Indranil
dc.contributor.author
Villaescusa, J. Carlos
dc.contributor.author
Levanon, Ditsa
dc.contributor.author
Wang, Yiqiao
dc.contributor.author
Franck, Marina C. M.
dc.contributor.author
Kharchenko, Olga
dc.contributor.author
Adameyko, Igor
dc.contributor.author
Linnarsson, Sten
dc.contributor.author
Groner, Yoram
dc.contributor.author
Turner, Eric
dc.contributor.author
Ernfors, Patrik
dc.date.available
2020-01-29T20:51:28Z
dc.date.issued
2012-09
dc.identifier.citation
Lallemend, Francois; Sterzenbach, Ulrich; Hadjab Lallemend, Saida; Aquino, Jorge Benjamin; Castelo Branco, Goncalo; et al.; Positional differences of axon growth rates between sensory neurons encoded by runx3; Nature Publishing Group; Embo Journal; 31; 18; 9-2012; 3718-3729
dc.identifier.issn
0261-4189
dc.identifier.uri
http://hdl.handle.net/11336/96181
dc.description.abstract
The formation of functional connectivity in the nervous system is governed by axon guidance that instructs nerve growth and branching during development, implying a similarity between neuronal subtypes in terms of nerve extension. We demonstrate the molecular mechanism of another layer of complexity in vertebrates by defining a transcriptional program underlying growth differences between positionally different neurons. The rate of axon extension of the early subset of embryonic dorsal root ganglion sensory neurons is encoded in neurons at different axial levels. This code is determined by a segmental pattern of axial levels of Runx family transcription factor Runx3. Runx3 in turn determines transcription levels of genes encoding cytoskeletal proteins involved in axon extension, including Rock1 and Rock2 which have ongoing activities determining axon growth in early sensory neurons and blocking Rock activity reverses axon extension deficits of Runx3−/− neurons. Thus, Runx3 acts to regulate positional differences in axon extension properties apparently without affecting nerve guidance and branching, a principle that could be relevant to other parts of the nervous system.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AXON GROWTH
dc.subject
DEVELOPMENT
dc.subject
INTRINSIC
dc.subject
RUNX3
dc.subject.classification
Biología del Desarrollo
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Positional differences of axon growth rates between sensory neurons encoded by runx3
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-01-29T15:43:04Z
dc.journal.volume
31
dc.journal.number
18
dc.journal.pagination
3718-3729
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Lallemend, Francois. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Sterzenbach, Ulrich. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Hadjab Lallemend, Saida. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Aquino, Jorge Benjamin. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Castelo Branco, Goncalo. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Sinha, Indranil. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Villaescusa, J. Carlos. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Levanon, Ditsa. The Weizmann Institute of Science; Israel
dc.description.fil
Fil: Wang, Yiqiao. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Franck, Marina C. M.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Kharchenko, Olga. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Adameyko, Igor. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Linnarsson, Sten. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Groner, Yoram. The Weizmann Institute of Science; Israel
dc.description.fil
Fil: Turner, Eric. Seattle Children's Research Institute; Estados Unidos
dc.description.fil
Fil: Ernfors, Patrik. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.journal.title
Embo Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.embopress.org/doi/10.1038/emboj.2012.228
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1038%2Femboj.2012.228
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442276/#!po=75.0000
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