Artículo
Fructose-rich diet-induced abdominal adipose tissue endocrine dysfunction in normal male rats
Alzamendi, Ana
; Giovambattista, Andres
; Raschia, Maria Agustina
; Madrid, Viviana Graciela
; Gaillard, Rolf C.; Rebolledo, Oscar; Gagliardino, Juan Jose
; Spinedi, Eduardo Julio
Fecha de publicación:
04/2009
Editorial:
Humana Press
Revista:
Endocrine
ISSN:
1355-008X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
We have currently studied the changes induced by administration of a fructose-rich diet (FRD) to normal rats in the mass and the endocrine function of abdominal (omental) adipose tissue (AAT). Rats were fed ad libitum a standard commercial chow and tap water, either alone (control diet, CD) or containing fructose (10%, w/vol) (FRD). Three weeks after treatment, circulating metabolic markers and leptin release from adipocytes of AAT were measured. Plasma free fatty acids (FFAs), leptin, adiponectin, and plasminogen activator inhibitor-1 (PAI-1) levels were significantly higher in FRD than in CD rats. AAT mass was greater in FRD than in CD rats and their adipocytes were larger, they secreted more leptin and showed impaired insulin sensitivity. While leptin mRNA expression increased in AAT from FRD rats, gene expression of insulin receptor substrate, IRS1 and IRS2 was significantly reduced. Our study demonstrates that administration of a FRD significantly affects insulin sensitivity and several AAT endocrine/metabolic functions. These alterations could be part of a network of interacting abnormalities triggered by FRD-induced oxidative stress at the AAT level. In view of the impaired glucose tolerance observed in FRD rats, these alterations could play a key role in both the development of metabolic syndrome (MS) and β-cell failure.
Palabras clave:
ADIPOKINES
,
DEXAMETHASONE
,
INSULIN SIGNALLING
,
LIPIDS
,
METABOLIC SYNDROME
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Articulos(CENEXA)
Articulos de CENTRO DE ENDOCRINOLOGIA EXP.Y APLICADA (I)
Articulos de CENTRO DE ENDOCRINOLOGIA EXP.Y APLICADA (I)
Citación
Alzamendi, Ana; Giovambattista, Andres; Raschia, Maria Agustina; Madrid, Viviana Graciela; Gaillard, Rolf C.; et al.; Fructose-rich diet-induced abdominal adipose tissue endocrine dysfunction in normal male rats; Humana Press; Endocrine; 35; 2; 4-2009; 227-232
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