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dc.contributor.author
Vermeulen, Elba Monica
dc.contributor.author
Giordano, Mirta Nilda
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Trevani, Analía Silvina
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Sedlik, Christine
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Gamberale, Romina
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Fernández Calotti, Paula
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Salamone, Gabriela Veronica
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Raiden, Silvina Claudia
dc.contributor.author
Sanjurjo, Julieta
dc.contributor.author
Geffner, Jorge Raúl
dc.date.available
2020-01-28T15:45:51Z
dc.date.issued
2004-03
dc.identifier.citation
Vermeulen, Elba Monica; Giordano, Mirta Nilda; Trevani, Analía Silvina; Sedlik, Christine; Gamberale, Romina; et al.; Acidosis Improves Uptake of Antigens and MHC Class I-Restricted Presentation by Dendritic Cells; American Association of Immunologists; Journal of Immunology; 172; 5; 3-2004; 3196-3204
dc.identifier.issn
0022-1767
dc.identifier.uri
http://hdl.handle.net/11336/95967
dc.description.abstract
It is widely appreciated that inflammatory responses in peripheral tissues are usually associated to the development of acidic microenvironments. Despite this, there are few studies aimed to analyze the effect of extracellular pH on immune cell functions. We analyzed the impact of acidosis on the behavior of dendritic cells (DCs) derived from murine bone marrow. We found that extracellular acidosis (pH 6.5) markedly stimulated the uptake of FITC-OVA, FITC-dextran, and HRP by DCs. In fact, to reach similar levels of endocytosis, DCs cultured at pH 7.3 required concentrations of Ag in the extracellular medium almost 10-fold higher compared with DCs cultured at pH 6.5. Not only the endocytic capacity of DCs was up-regulated by extracellular acidosis, but also the expression of CD11c, MHC class II, CD40, and CD86 as well as the acquisition of extracellular Ags by DCs for MHC class I-restricted presentation. Importantly, DCs pulsed with Ag under acidosis showed an improved efficacy to induce both specific CD8+ CTLs and specific Ab responses in vivo. Our results suggest that extracellular acidosis improves the Ag-presenting capacity of DCs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Association of Immunologists
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
dendritic cell
dc.subject
acidosis
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Acidosis Improves Uptake of Antigens and MHC Class I-Restricted Presentation by Dendritic Cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-10T19:32:09Z
dc.journal.volume
172
dc.journal.number
5
dc.journal.pagination
3196-3204
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Bethesda
dc.description.fil
Fil: Vermeulen, Elba Monica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
dc.description.fil
Fil: Giordano, Mirta Nilda. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Trevani, Analía Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Sedlik, Christine. Institut National de la Santé et de la Recherche Médicale; Francia
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Fil: Gamberale, Romina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Fernández Calotti, Paula. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Salamone, Gabriela Veronica. Academia Nacional de Medicina de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Raiden, Silvina Claudia. Academia Nacional de Medicina de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Sanjurjo, Julieta. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Geffner, Jorge Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.journal.title
Journal of Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.jimmunol.org/content/172/5/3196
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4049/jimmunol.172.5.3196
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