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dc.contributor.author
Scollon, Edward J.
dc.contributor.author
Starr, James M.
dc.contributor.author
Crofton, Kevin M.
dc.contributor.author
Wolansky, Marcelo Javier
dc.contributor.author
DeVito, Michael J.
dc.contributor.author
Hughes, Michael F.
dc.date.available
2020-01-27T19:21:24Z
dc.date.issued
2011-11
dc.identifier.citation
Scollon, Edward J.; Starr, James M.; Crofton, Kevin M.; Wolansky, Marcelo Javier; DeVito, Michael J.; et al.; Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat; Elsevier Ireland; Toxicology; 290; 1; 11-2011; 1-6
dc.identifier.issn
0300-483X
dc.identifier.uri
http://hdl.handle.net/11336/95882
dc.description.abstract
The potential for human exposure to pyrethroid pesticides has prompted pharmacodynamic and pharmacokinetic research to better characterize risk. This work tested the hypothesis that blood and brain concentrations of the pyrethroid bifenthrin are predictive of neurotoxic effects. Adult male Long Evans rats received a single oral dose of bifenthrin dissolved in corn oil. Using figure-eight mazes, motor activity was measured for 1h at 4- and 7-h following exposure to bifenthrin (0-16mg/kg or 0-9mg/kg, respectively; n=4-8/group). Whole blood and brains were collected immediately following motor activity assays. Bifenthrin concentrations in blood and brain were quantified using HPLC/MS/MS. Bifenthrin exposure decreased motor activity from 20% to 70% in a dose-dependent manner at both time points. The relationship between motor activity data and administered dose, and blood and brain bifenthrin concentrations were described using a sigmoidal E max model. The relationships between motor activity and administered dose or blood concentrations were different between the 4- and 7-h time points. The relationship between motor activity and brain concentration was not significantly different between the two time points. These data suggest that momentary brain concentration of bifenthrin may be a more precise dose metric for predicting behavioral effects because the relationship between brain concentration and locomotor activity is independent of the time of exposure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BIFENTHRIN
dc.subject
BLOOD CONCENTRATIONS
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BRAIN CONCENTRATIONS
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MOTOR ACTIVITY
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-11-08T15:09:07Z
dc.journal.volume
290
dc.journal.number
1
dc.journal.pagination
1-6
dc.journal.pais
Irlanda
dc.description.fil
Fil: Scollon, Edward J.. National Health And Environmental Effects Research Laboratory; Estados Unidos
dc.description.fil
Fil: Starr, James M.. United States Environmental Protection Agency; Estados Unidos
dc.description.fil
Fil: Crofton, Kevin M.. National Health And Environmental Effects Research Laboratory; Estados Unidos
dc.description.fil
Fil: Wolansky, Marcelo Javier. National Research Council; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: DeVito, Michael J.. National Health And Environmental Effects Research Laboratory; Estados Unidos
dc.description.fil
Fil: Hughes, Michael F.. National Health And Environmental Effects Research Laboratory; Estados Unidos
dc.journal.title
Toxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0300483X11002939
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682199/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.tox.2011.08.002
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