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dc.contributor.author
Rittler, Monica
dc.contributor.author
Cosentino, Viviana Raquel
dc.contributor.author
López Camelo, Jorge Santiago
dc.contributor.author
Murray, Jeffrey C.
dc.contributor.author
Wehby, George
dc.contributor.author
Castilla, Eduardo Enrique
dc.date.available
2020-01-21T20:21:04Z
dc.date.issued
2011-07
dc.identifier.citation
Rittler, Monica; Cosentino, Viviana Raquel; López Camelo, Jorge Santiago; Murray, Jeffrey C.; Wehby, George; et al.; Associated anomalies among infants with oral clefts at birth and during a 1-year follow-up; Wiley-liss, Div John Wiley & Sons Inc; American Journal of Medical Genetics Part A; 155; 7; 7-2011; 1588-1596
dc.identifier.issn
1552-4825
dc.identifier.uri
http://hdl.handle.net/11336/95465
dc.description.abstract
Reports of birth defects rates may focus on defects observed in the newborn period or include defects diagnosed at older ages. However, little information is available on the rates of additional anomalies detected after birth or on the ages at which such anomalies are diagnosed. The aims of this work were to describe the initial diagnoses of oral clefts, isolated or associated with other defects, in newborn infants ascertained in hospitals of the ECLAMC network, and diagnostic changes that occurred due to detection of additional defects during a 1-year follow-up period. Seven hundred ten liveborn infants with cleft lip only (CLO), cleft lip with cleft palate (CLP), or cleft palate (CP) were ascertained between 2003 and 2005. Prevalence estimates of isolated and associated (ASO) clefts, diagnoses in infants with associated clefts, and the percentage of isolated clefts that were reclassified as associated were established. Birth prevalence estimates (per 1,000) were as follows: Total: 1.7; CLP: 0.94 (ASO=23.5%); CP: 0.46 (ASO=42.3%); CLO: 0.28 (ASO=7.6%). Initial diagnoses in infants with associated clefts included 38 infants with chromosomal abnormalities, 33 with non-chromosomal syndromes, 16 with malformation sequences, and 98 with multiple anomalies of unknown etiology. Seven percent of newborns initially classified as isolated were later reclassified as associated. Ten infants without associated defects or clinically suspected syndromes were diagnosed as syndromic only through laboratory findings or family history, illustrating the difference between the terms associated versus isolated, which refers to presence or absence of associated anomalies, and syndromic versus non-syndromic, which refers to etiology.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ASSOCIATED
dc.subject
FOLLOW-UP
dc.subject
ISOLATED
dc.subject
ORAL CLEFTS
dc.subject
SYNDROMIC
dc.subject.classification
Epidemiología
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Associated anomalies among infants with oral clefts at birth and during a 1-year follow-up
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-24T17:36:46Z
dc.journal.volume
155
dc.journal.number
7
dc.journal.pagination
1588-1596
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Rittler, Monica. Provincia de Buenos Aires. Hospital Materno Infantil Ramón Sardá; Argentina. Organizacion Mundial de la Salud; Argentina
dc.description.fil
Fil: Cosentino, Viviana Raquel. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
dc.description.fil
Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
dc.description.fil
Fil: Murray, Jeffrey C.. University of Iowa; Estados Unidos
dc.description.fil
Fil: Wehby, George. University of Iowa; Estados Unidos
dc.description.fil
Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Fundación Oswaldo Cruz; Brasil
dc.journal.title
American Journal of Medical Genetics Part A
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650830/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.a.34046
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1002/ajmg.a.34046
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