Artículo
Keeping dry and crossing membranes
Fecha de publicación:
09/2004
Editorial:
Nature Publishing Group
Revista:
Nature Biotechnology
ISSN:
1087-0156
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Water sustains life but also imposes constraints on what life should be like. Its high dipole moment, proton donor-acceptor dual nature and rotational freedom make it a powerful former of hydrogen bonds. In solu- ble proteins, this property places stringent constraints on the way proteins interact (1-4) and fold (5). I argue here that the manipulation of intramolecularly underdehydrated or underwrapped electrostatic interactions in proteins can be exploited in engineering strategies to create molecules with an enhanced ability to traverse biological membranes, with potential implications for oral delivery of peptide-based drugs.
Palabras clave:
TRANSLOCATION
,
BIOTECHNOLOGY
,
GLUCAGON
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INMABB)
Articulos de INST.DE MATEMATICA BAHIA BLANCA (I)
Articulos de INST.DE MATEMATICA BAHIA BLANCA (I)
Citación
Fernandez, Ariel; Keeping dry and crossing membranes; Nature Publishing Group; Nature Biotechnology; 22; 9; 9-2004; 1081-1084
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