Artículo

DNA and chromosome damage induced by bleomycin in mammalian cells: An update

Bolzan, Alejandro DanielIcon ; Bianchi, Martha S.
Fecha de publicación: 01/2018
Editorial: Elsevier Science
Revista: Mutation Research. Reviews In Mutation Research
ISSN: 1383-5742
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Bleomycin (BLM) is an antibiotic isolated from Streptomyces verticillus. It has radiomimetic actions on DNA thus it has been widely used in clinical chemotherapy for the treatment of different types of cancer, including head and neck tumors, lymphomas, squamous-cell carcinomas and germ-cell tumors. Because of this, the study of BLM genotoxicity is of practical interest. This antibiotic is an S-independent clastogen and an agent that generates free radicals and induces single- and double-strand breaks in DNA. In the present review, we will summarize our current knowledge concerning the DNA and chromosome damage induced by BLM in mammalian cells, with emphasis on new developments published since 1991.
Palabras clave: BLEOMYCIN , GENOTOXICITY , CHROMOSOMAL ABERRATIONS , DNA DAMAGE , TELOMERE
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/95309
URL: https://www.sciencedirect.com/science/article/pii/S1383574217301205
DOI: http://dx.doi.org/10.1016/j.mrrev.2018.02.003
Colecciones
Articulos(IMBICE)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA CELULAR (I)
Citación
Bolzan, Alejandro Daniel; Bianchi, Martha S.; DNA and chromosome damage induced by bleomycin in mammalian cells: An update; Elsevier Science; Mutation Research. Reviews In Mutation Research; 775; 1-2018; 51-62
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