Artículo
Microglia-precursor cell interactions in health and in pathology
Fecha de publicación:
11/2018
Editorial:
Instituto de Histología y Embriología "Dr. Mario Burgos"
Revista:
Biocell
e-ISSN:
1667-5746
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Until recently, microglia were mainly known as the resident phagocytes of the brain, i.e. the ‘immunological warriors’ of the brain. However, extensive knowledge is being accumulated about the functions of microglia beyond immunity. Nowadays, it is well accepted that microglial cells are highly dynamic and responsive, and that they intervene in a dual manner in many developmental processes that shape the central nervous system, including neurogenesis, gliogenesis, spatial patterning, synaptic formation and elimination, and neural circuit establishment and maturation. The differentiation and the pool of precursor cells were also shown to be under microglia regulation via bidirectional communication. In this concise review, I discuss our recent work in microglia-Pax6+ cell interactions in one of the circumventricular organs, the pineal gland. An analogy with the rest of the central nervous system is also presented. In addition, I briefly examine mechanisms of interaction between microglia and non-microglial cells in both health and disease. New avenues are also introduced, which may lead us to better comprehend the impact of microglia in physiological and pathological conditions.
Palabras clave:
PHAGOCYTE
,
PHAGOCYTOSIS
,
PHAGOPTOSIS
,
APOPTOSIS
,
AUTOPHAGY
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IHEM)
Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS
Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS
Citación
Muñoz, Estela Maris; Microglia-precursor cell interactions in health and in pathology; Instituto de Histología y Embriología "Dr. Mario Burgos"; Biocell; 42; 2; 11-2018; 41-45
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