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dc.contributor.author
Joo Turoni, Claudio Martín
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Peral, Maria de Los Angeles
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Coviello, Alfredo
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Marañón, Rodrigo Oscar
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Herrera, Ramon Nicasio Gerardo
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Muntaner, Juan
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Proto, Victor
dc.date.available
2020-01-20T18:36:54Z
dc.date.issued
2007-06
dc.identifier.citation
Joo Turoni, Claudio Martín; Peral, Maria de Los Angeles; Coviello, Alfredo; Marañón, Rodrigo Oscar; Herrera, Ramon Nicasio Gerardo; et al.; Internal mammary artery grafts reactivity in hypertensive patients: Role of stretching in extraendothelial nitric oxide; Taylor & Francis; Clinical and Experimental Hypertension; 29; 6-2007; 327-344
dc.identifier.issn
1064-1963
dc.identifier.uri
http://hdl.handle.net/11336/95242
dc.description.abstract
Background. The internal mammary artery (IMA) used in bypass coronary surgery remains efficient for a longer time than other grafts, such as saphenous veins; however, its biological characteristics are incompletely defined. Objective. To compare in IMA grafts from hypertensive (HT) and normotensive (NT) patients the presence of endothelium and their functionability, the response to passive stretching and basal tone, the reactivity to exogenous vasoconstrictors, the role of stretching in NO release, and the possible extraendothelial NO source. Methods and Results. IMA rings contractility, presence of endothelium, and nitrite release were studied. An endothelial dysfunction associated with hypertension was found. IMA rings from HT had an impaired response to passive stretching, resulting in a decreased relaxation. All IMA grafts had an increased basal tone demonstrated by relaxation to SNP; however, a lesser response was found in HT. Interestingly, it was demonstrated that NO release was present in IMA grafts, despite an endothelial dysfunction and that stretching increased NO release. This effect was inhibited by Ca2+-free media, L-NAME and a specific neuronal NO synthase (nNOS) inhibitor. Furthermore, the demonstration of the presence of nNOS in smooth muscle cells by immunohistochemistry supports a role of extraendothelial NO. Conclusion. We demonstrate the impact of hypertension in IMA grafts producing increased endothelial dysfunction, reduced response to passive stretching, increased basal tone, and impaired responsiveness to exogenous vasoconstrictors and NO release. A specific role of stretching in extraendothelial NO release was demonstrated, which may have an important role in the outcome of IMA grafts due to the protective actions of NO, even in the absence of the endothelium.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ENDOTHELIAL DYSFUNCTION
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EXTRAENDOTHELIAL NITRIC OXIDE SYNTHASE
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HYPERTENSION
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IMA GRAFTS
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VASCULAR REACTIVITY
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Otras Ciencias Médicas
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Otras Ciencias Médicas
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Internal mammary artery grafts reactivity in hypertensive patients: Role of stretching in extraendothelial nitric oxide
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-05-27T17:05:12Z
dc.journal.volume
29
dc.journal.pagination
327-344
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Londres
dc.description.fil
Fil: Joo Turoni, Claudio Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Coviello, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Marañón, Rodrigo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
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Fil: Herrera, Ramon Nicasio Gerardo. Centro Modelo de Cardiología; Argentina
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Fil: Muntaner, Juan. Centro Modelo de Cardiología; Argentina
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Fil: Proto, Victor. Centro Modelo de Cardiología; Argentina
dc.journal.title
Clinical and Experimental Hypertension
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/10641960701500570
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/10641960701500570