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dc.contributor.author
Grunhut, Marcos
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dc.contributor.author
Centurión, María Eugenia
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dc.contributor.author
Fragoso, Wallace D.
dc.contributor.author
Almeida, Luciano F.
dc.contributor.author
de Araújo, Mário C.U.
dc.contributor.author
Fernández Band, Beatriz Susana
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dc.date.available
2020-01-17T21:34:48Z
dc.date.issued
2008-05
dc.identifier.citation
Grunhut, Marcos; Centurión, María Eugenia; Fragoso, Wallace D.; Almeida, Luciano F.; de Araújo, Mário C.U.; et al.; Flow-batch technique for the simultaneous enzymatic determination of levodopa and carbidopa in pharmaceuticals using PLS and successive projections algorithm; Elsevier Science; Talanta; 75; 4; 5-2008; 950-958
dc.identifier.issn
0039-9140
dc.identifier.uri
http://hdl.handle.net/11336/95144
dc.description.abstract
An enzymatic flow-batch system with spectrophotometric detection was developed for simultaneous determination of levodopa [(S)-2 amino-3-(3,4-dihydroxyphenyl)propionic acid] and carbidopa [(S)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methylpropionic acid] in pharmaceutical preparations. The data were analysed by univariate method, partial least squares (PLS) and a novel variable selection for multiple lineal regression (MLR), the successive projections algorithm (SPA). The enzyme polyphenol oxidase (PPO; EC 1.14.18.1) obtained from Ipomoea batatas (L.) Lam. was used to oxidize both analytes to their respective dopaquinones, which presented a strong absorption between 295 and 540 nm. The statistical parameters (RMSE and correlation coefficient) calculated after the PLS in the spectral region between 295 and 540 nm and MLR-SPA application were appropriate for levodopa and carbidopa. A comparative study of univariate, PLS, in different ranges, and MLR-SPA chemometrics models, was carried out by applying the elliptical joint confidence region (EJCR) test. The results were satisfactory for PLS in the spectral region between 295 and 540 nm and for MLR-SPA. Tablets of commercial samples were analysed and the results obtained are in close agreement with both, spectrophotometric and HPLC pharmacopeia methods. The sample throughput was 18 h-1.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CARBIDOPA
dc.subject
FLOW-BATCH
dc.subject
LEVODOPA
dc.subject
MLR-SPA
dc.subject
PLS
dc.subject
POLYPHENOL OXIDASE
dc.subject.classification
Química Analítica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Flow-batch technique for the simultaneous enzymatic determination of levodopa and carbidopa in pharmaceuticals using PLS and successive projections algorithm
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-11-04T15:25:01Z
dc.journal.volume
75
dc.journal.number
4
dc.journal.pagination
950-958
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Grunhut, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Centurión, María Eugenia. Universidad Nacional del Sur. Departamento de Química; Argentina
dc.description.fil
Fil: Fragoso, Wallace D.. Universidade Federal da Paraíba; Brasil
dc.description.fil
Fil: Almeida, Luciano F.. Universidade Federal da Paraíba; Brasil
dc.description.fil
Fil: de Araújo, Mário C.U.. Universidade Federal da Paraíba; Brasil
dc.description.fil
Fil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.journal.title
Talanta
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0039914007008879
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.talanta.2007.12.029
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