Artículo
Differential gene expression induced by chronic levodopa treatment in the striatum of rats with lesions of the nigrostriatal system
Ferrario, Juan Esteban
; Taravini, Irene Rita Eloisa
; Mourlevat, Sophie; Stefano, Andrea; Delfino, Marina A.; Raisman Vozari, Rita; Murer, Mario Gustavo
; Ruberg, Merle; Gershanik, Oscar Samuel
Fecha de publicación:
09/2004
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Journal of Neurochemistry
ISSN:
0022-3042
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Levodopa, the major treatment for patients with Parkinson's disease, has been shown to induce a variety of compensatory effects, including facilitation of sprouting by dopaminergic neurons, in experimental animals with lesions leading to denervation of the striatum. To better understand the cellular and molecular environment where most of these compensatory changes take place, in particular elements that might contribute to the recovery of dopaminergic innervation, we have constructed a differential expression library enriched in transcripts from the striata of rats with lesions of the medial forebrain bundle treated with levodopa for 6 months. We have used this library to screen an expression array of rat genes representing the major cell functions, and have identified several that are involved in neurotrophic mechanisms and plasticity. We have confirmed the differential expression of selected transcripts by non‐radioactive in situ hybridization, and report that the growth factor pleiotrophin, myelin basic protein and calmodulin are overexpressed in the denervated striatum of levodopa‐treated rats.
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Articulos(ININFA)
Articulos de INST.DE INVEST.FARMACOLOGICAS (I)
Articulos de INST.DE INVEST.FARMACOLOGICAS (I)
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Ferrario, Juan Esteban; Taravini, Irene Rita Eloisa; Mourlevat, Sophie; Stefano, Andrea; Delfino, Marina A.; et al.; Differential gene expression induced by chronic levodopa treatment in the striatum of rats with lesions of the nigrostriatal system; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 90; 6; 9-2004; 1348-1358
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