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dc.contributor.author
Cela, Eliana Maiten
dc.contributor.author
Gonzalez, Cintia Daniela
dc.contributor.author
Friedrich, Adrián David
dc.contributor.author
Ledo, Camila
dc.contributor.author
Paz, Mariela Laura
dc.contributor.author
Leoni, Juliana
dc.contributor.author
Gomez, Marisa Ines
dc.contributor.author
Gonzalez Maglio, Daniel Horacio
dc.date.available
2020-01-14T18:16:03Z
dc.date.issued
2018-07
dc.identifier.citation
Cela, Eliana Maiten; Gonzalez, Cintia Daniela; Friedrich, Adrián David; Ledo, Camila; Paz, Mariela Laura; et al.; Daily very low UV dose exposure enhances adaptive immunity, compared with a single high‐dose exposure. Consequences for the control of a skin infection; Wiley Blackwell Publishing, Inc; Immunology; 154; 3; 7-2018; 510-521
dc.identifier.issn
0019-2805
dc.identifier.uri
http://hdl.handle.net/11336/94629
dc.description.abstract
Ultraviolet radiation (UVr) promotes several well‐known molecular changes, which may ultimately impact on health. Some of these effects are detrimental, like inflammation, carcinogenesis and immunosuppression. On the other hand, UVr also promotes vitamin D synthesis and other beneficial effects. We recently demonstrated that exposure to very low doses of UVr on four consecutive days [repetitive low UVd (rlUVd)] does not promote an inflammatory state, nor the recruitment of neutrophils or lymphocytes, as the exposure to a single high UV dose (shUVd) does. Moreover, rlUVd reinforce the epithelium by increasing antimicrobial peptides transcription and epidermal thickness. The aim of this study was to evaluate the adaptive immune response after shUVd and rlUVd, determining T‐cell and B‐cell responses. Finally, we challenged animals exposed to both irradiation procedures with Staphylococcus aureus to study the overall effects of both innate and adaptive immunity during a cutaneous infection. We observed, as expected, a marked suppression of T‐cell and B‐cell responses after exposure to an shUVd but a novel and significant increase in both specific responses after exposure to rlUVd. However, the control of the cutaneous S. aureus infection was defective in this last group, suggesting that responses against pathogens cannot be ruled out from isolated stimuli.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BACTERIAL INFECTION
dc.subject
IMMUNE STIMULATION
dc.subject
IMMUNE SUPPRESSION
dc.subject
SKIN
dc.subject
ULTRAVIOLET RADIATION
dc.subject.classification
Enfermedades Infecciosas
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Enfermedades Infecciosas
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Daily very low UV dose exposure enhances adaptive immunity, compared with a single high‐dose exposure. Consequences for the control of a skin infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-02T19:41:58Z
dc.journal.volume
154
dc.journal.number
3
dc.journal.pagination
510-521
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.journal.title
Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1111/imm.12901
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/imm.12901


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