Artículo
Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device
Luján, Emmanuel
; Schinca, Herman; Olaiz, Nahuel Manuel
; Urquiza, Santiago Adrian; Molina, Fernando Víctor
; Turjanski, Pablo Guillermo
; Marshall, Guillermo Ricardo
Fecha de publicación:
12/2015
Editorial:
Pergamon-Elsevier Science Ltd
Revista:
Electrochimica Acta
ISSN:
0013-4686
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Electrolytic ablation (EA), a medical treatment used in solid tumor ablation due to its minimum side effects and low cost, consists in the passage of a low constant electric current through two or more electrodes inserted in the tissue thus inducing pH fronts that produce tumor necrosis. Combined with a recently introduced one-probe two electrode device (OPTED) this procedure results in a minimally invasive treatment. Despite its success, EA has drawbacks such as the difficulties in determining the optimum dose-response relationship between the applied current, treatment time and necrotized tumor volume (NTV) and choosing a reliable dose parameter. In this work, a theoretical model is introduced describing the EA/OPTED as an electrolytic process and the underlying electrochemical reactions through the Nernst-Planck equations for ion transport. Model results show that the coulomb dosage is a reliable dose parameter and predicts an optimal dose-response relationship for a given tumor size subjected to an EA/OPTED, considering the optimum as the minimum coulomb dosage necessary to achieve total tumor destruction while minimizing healthy tissue damage. Moreover, it predicts a nonlinear relationship between coulomb dosage and NTV, dosage and NTV scaling as Q1.4. Consequently, these results could have a significant impact on dose planning methodology aimed at improving the effectiveness of the electrolytic ablation.
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Articulos(INFINA)
Articulos de INST.DE FISICA DEL PLASMA
Articulos de INST.DE FISICA DEL PLASMA
Articulos(INQUIMAE)
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Citación
Luján, Emmanuel; Schinca, Herman; Olaiz, Nahuel Manuel; Urquiza, Santiago Adrian; Molina, Fernando Víctor; et al.; Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device; Pergamon-Elsevier Science Ltd; Electrochimica Acta; 186; 12-2015; 494-503
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