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dc.contributor.author
Ferrero, Alejandro Javier
dc.contributor.author
Cereseto, Marina
dc.contributor.author
Reines, Analia Gabriela
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Bonavita, Carla D.
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Sifonios, Laura Lucrecia
dc.contributor.author
Rubio, Modesto Carlos
dc.contributor.author
Wikinski, Silvia Ines
dc.date.available
2020-01-13T20:01:54Z
dc.date.issued
2005-06
dc.identifier.citation
Ferrero, Alejandro Javier; Cereseto, Marina; Reines, Analia Gabriela; Bonavita, Carla D.; Sifonios, Laura Lucrecia; et al.; Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release; Pergamon-Elsevier Science Ltd; Progress of Neuro-psychopharmacology and Biological Psychiatry; 29; 5; 6-2005; 678-686
dc.identifier.issn
0278-5846
dc.identifier.uri
http://hdl.handle.net/11336/94572
dc.description.abstract
The proconvulsive effect of the new generation of antidepressants remains controversial. The authors investigated in naïve rats the effect of chronic treatment with fluoxetine (FLX) on the convulsive threshold and on two parameters of the hippocampal glutamatergic neurotransmission: the in vitro glutamate release and the binding of [3H] MK801 to NMDA receptors. While the acute treatment with FLX provoked no change either in seizure susceptibility or in the glutamate release, the chronic treatment decreased the convulsive threshold in coincidence with an increment in the in vitro glutamate release. No significant effects on the binding of [3H] MK801 to NMDA receptors were found to be attributable to the FLX treatment. We also assessed the effect of the chronic treatment with FLX on the seizure threshold in rats exposed to an experimental model of depression, the learned helplessness paradigm (LH). While a decrease in the K+-stimulated glutamate release was observed in non treated LH animals, when they were chronically injected with FLX, no changes in the epileptic susceptibility and no increments in the glutamate release were found. Our results indicate that chronic treatment with FLX decreases the epileptic threshold in naïve but not in LH rats and that this effect correlates with the levels of the hippocampal glutamate release.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHRONIC TREATMENT
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FLUOXETINE
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GLUTAMATE RELEASE
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HIPPOCAMPUS
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LEARNED HELPLESSNESS
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SEIZURE THRESHOLD
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Farmacología y Farmacia
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-11-25T17:45:42Z
dc.journal.volume
29
dc.journal.number
5
dc.journal.pagination
678-686
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Carabajal Ferrero, Claudio Marcelo. Hospital Italiano; Argentina
dc.description.fil
Fil: Cereseto, Marina. ININFA; Argentina
dc.description.fil
Fil: Reines, Analia Gabriela. ININFA; Argentina
dc.description.fil
Fil: Bonavita, Liliana Noemi. NINFA; Argentina
dc.description.fil
Fil: Sifonios, Laura Lucrecia. ININFA; Argentina
dc.description.fil
Fil: Rubio, Modesto Carlos. ININFA; Argentina
dc.description.fil
Fil: Wikinski, Silvia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina. ININFA; Argentina
dc.journal.title
Progress of Neuro-psychopharmacology and Biological Psychiatry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0278584605001326
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.pnpbp.2005.04.013
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