Mostrar el registro sencillo del ítem
dc.contributor.author
Taravini, Irene Rita Eloisa
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Ferrario, Juan Esteban
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Delbe, Jean
dc.contributor.author
Ginestet, Laure
dc.contributor.author
Debeir, Thomas
dc.contributor.author
Courty, José
dc.contributor.author
Murer, Mario Gustavo
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Gershanik, Oscar Samuel
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Raisman Vozari, Rita
dc.date.available
2020-01-10T20:32:11Z
dc.date.issued
2005-12
dc.identifier.citation
Taravini, Irene Rita Eloisa; Ferrario, Juan Esteban; Delbe, Jean; Ginestet, Laure; Debeir, Thomas; et al.; Immunodetection of heparin-binding growth associated molecule (pleiotrophin) in striatal interneurons; Elsevier Science; Brain Research; 1066; 1-2; 12-2005; 196-200
dc.identifier.issn
0006-8993
dc.identifier.uri
http://hdl.handle.net/11336/94392
dc.description.abstract
Pleiotrophin (PTN), a developmentally-regulated trophic factor, is over-expressed in the striatum of parkinsonian rats. Because striatal PTN can provide trophic support to dopamine neurons, we identified the cellular types containing PTN in the striatum of adult rats. By means of fluorescent double-immunolabeling, we found PTN to co-localize with a neuronal nuclei marker but not with glial fibrillary acidic protein. The number, distribution, and morphology of the PTN-immunolabeled cells suggested that they were interneurons. Further double-immunolabeling studies ruled out PTN localization to calretinin- and parvalbumin-containing interneurons. Instead, ∼40% of the PTN-immunolabeled neurons contained nitric oxide synthase or somatostatin and ∼60% expressed the vesicular acetylcholine transporter, supporting that they were GABAergic nitric oxide synthase/somatostatin-containing and cholinergic interneurons. Further work is necessary to determine if PTN from striatal interneurons can provide trophic support to dopamine neurons.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
PLEIOTROPHIN
dc.subject
STRIATAL INTERNEURON
dc.subject
IMMUNOHISTOCHEMISTRY
dc.subject
PARKINSON´S DISEASE
dc.subject.classification
Neurociencias
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Medicina Básica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Immunodetection of heparin-binding growth associated molecule (pleiotrophin) in striatal interneurons
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-11-25T17:46:08Z
dc.journal.volume
1066
dc.journal.number
1-2
dc.journal.pagination
196-200
dc.journal.pais
Países Bajos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Taravini, Irene Rita Eloisa.
dc.description.fil
Fil: Ferrario, Juan Esteban.
dc.description.fil
Fil: Jean Delbe.
dc.description.fil
Fil: Laure Ginestet.
dc.description.fil
Fil: Thomas Debeir.
dc.description.fil
Fil: José Courty.
dc.description.fil
Fil: M. Gustavo Murer. FACULTAD DE MEDICINA; Argentina
dc.description.fil
Fil: Gershanik, Oscar Samuel. ININFA; Argentina
dc.description.fil
Fil: Rita Raisman-Vozari.
dc.journal.title
Brain Research
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0006899305014460
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.brainres.2005.10.055
Archivos asociados