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dc.contributor.author
Tuppo, Ehab E.
dc.contributor.author
Arias, Hugo Rubén
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dc.date.available
2020-01-10T19:00:58Z
dc.date.issued
2005-02
dc.identifier.citation
Tuppo, Ehab E.; Arias, Hugo Rubén; The role of inflammation in Alzheimer's disease; Elsevier Science; International Journal of Biochemistry and Cellular Biology; 37; 2; 2-2005; 289-305
dc.identifier.issn
1357-2725
dc.identifier.uri
http://hdl.handle.net/11336/94334
dc.description.abstract
Considerable evidence gained over the past decade has supported the conclusion that neuroinflammation is associated with Alzheimer's disease (AD) pathology. Inflammatory components related to AD neuroinflammation include brain cells such as microglia and astrocytes, the classic and alternate pathways of the complement system, the pentraxin acute-phase proteins, neuronal-type nicotinic acetylcholine receptors (AChRs), peroxisomal proliferators-activated receptors (PPARs), as well as cytokines and chemokines. Both the microglia and astrocytes have been shown to generate beta-amyloid protein (Aβ), one of the main pathologic features of AD. Aβ itself has been shown to act as a pro-inflammatory agent causing the activation of many of the inflammatory components. Further substantiation for the role of neuroinflammation in AD has come from studies that demonstrate patients who took non-steroidal anti-inflammatory drugs had a lower risk of AD than those who did not. These same results have led to increased interest in pursuing anti-inflammatory therapy for AD but with poor results. On the other hand, increasing amount of data suggest that AChRs and PPARs are involved in AD-induced neuroinflammation and in this regard, future therapy may focus on their specific targeting in the AD brain.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ALZHEIMER'S DISEASE
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BETA-AMYLOID PROTEIN
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CHEMOKINES
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COMPLEMENT SYSTEM
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CYCLOOXYGENASE
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CYTOKINES
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GLIAL CELLS
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INTERLEUKIN
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NEUROINFLAMMATION
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NICOTINIC ACETYLCHOLINE RECEPTORS
dc.subject
NSAIDS
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PENTRAXINS
dc.subject
SENILE PLAQUES
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STEROIDS
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TUMOR NECROSIS FACTOR
dc.subject.classification
Patología
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dc.subject.classification
Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
The role of inflammation in Alzheimer's disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-12-18T13:56:13Z
dc.journal.volume
37
dc.journal.number
2
dc.journal.pagination
289-305
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Tuppo, Ehab E.. University of Medicine and Dentistry of New Jersey. School of Osteopathic Medicine. Center for Aging; Estados Unidos
dc.description.fil
Fil: Arias, Hugo Rubén. Western University of Health Sciences. College of Pharmacy. Department of Pharmaceutical Sciences; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Matemática Bahía Blanca. Universidad Nacional del Sur. Departamento de Matemática. Instituto de Matemática Bahía Blanca; Argentina
dc.journal.title
International Journal of Biochemistry and Cellular Biology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1357272504002699
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.biocel.2004.07.009
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