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dc.contributor.author
Neuner, Sarah M.
dc.contributor.author
Wilmott, Lynda A.
dc.contributor.author
Hope, Kevin A.
dc.contributor.author
Hoffmann, Brian
dc.contributor.author
Chong, Jayhong A.
dc.contributor.author
Abramowitz, Joel
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Birnbaumer, Lutz
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O'Connell, Kristen M.
dc.contributor.author
Tryba, Andrew K.
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Greene, Andrew S.
dc.contributor.author
Savio Chan, C.
dc.contributor.author
Kaczorowski, Catherine C.
dc.date.available
2020-01-09T20:41:27Z
dc.date.issued
2015-03
dc.identifier.citation
Neuner, Sarah M.; Wilmott, Lynda A.; Hope, Kevin A.; Hoffmann, Brian; Chong, Jayhong A.; et al.; TRPC3 channels critically regulate hippocampal excitability and contextual fear memory; Elsevier Science; Behavioural Brain Research; 281; 3-2015; 69-77
dc.identifier.issn
0166-4328
dc.identifier.uri
http://hdl.handle.net/11336/94231
dc.description.abstract
Memory formation requires de novo protein synthesis, and memory disorders may result from misregulated synthesis of critical proteins that remain largely unidentified. Plasma membrane ion channels and receptors are likely candidates given their role in regulating neuron excitability, a candidate memory mechanism. Here we conduct targeted molecular monitoring and quantitation of hippocampal plasma membrane proteins from mice with intact or impaired contextual fear memory to identify putative candidates. Here we report contextual fear memory deficits correspond to increased Trpc3 gene and protein expression, and demonstrate TRPC3 regulates hippocampal neuron excitability associated with memory function. These data provide a mechanistic explanation for enhanced contextual fear memory reported herein following knockdown of TRPC3 in hippocampus. Collectively, TRPC3 modulates memory and may be a feasible target to enhance memory and treat memory disorders.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
AFTERHYPERPOLOARIZATION
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AGING
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HIPPOCAMPUS
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MEMORY
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PROTEOMICS
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TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
TRPC3 channels critically regulate hippocampal excitability and contextual fear memory
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-28T18:25:07Z
dc.journal.volume
281
dc.journal.pagination
69-77
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Neuner, Sarah M.. The University of Tennessee Health Science Center. Department of Anatomy and Neurobiology; Estados Unidos
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Fil: Wilmott, Lynda A.. The University of Tennessee Health Science Center. Department of Anatomy and Neurobiology; Estados Unidos
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Fil: Hope, Kevin A.. The University of Tennessee Health Science Center. Department of Anatomy and Neurobiology; Estados Unidos
dc.description.fil
Fil: Hoffmann, Brian. Medical College of Wisconsin. Department of Biotechnology and Bioengineering; Estados Unidos
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Fil: Chong, Jayhong A.. MA. Hydra Biosciences, Cambridge; Estados Unidos
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Fil: Abramowitz, Joel. Research Triangle Park. Laboratory of Neurobiology. National Institute of Environmental Health Sciences; Estados Unidos
dc.description.fil
Fil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Research Triangle Park. Laboratory of Neurobiology. National Institute of Environmental Health Sciences; Estados Unidos
dc.description.fil
Fil: O'Connell, Kristen M.. University of Tennessee Health Science Center. Department of Physiology; Estados Unidos
dc.description.fil
Fil: Savio, Chan C.. Northwestern Fienberg School of Medicine. Department of Physiology; Estados Unidos
dc.description.fil
Fil: Kaczorowski, Catherine C.. The University of Tennessee Health Science Center. Department of Anatomy and Neurobiology; Estados Unidos
dc.journal.title
Behavioural Brain Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432814008122
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbr.2014.12.018
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