Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide

Ramhorst, Rosanna ElizabethIcon ; Calo, GuillerminaIcon ; Paparini, Daniel EstebanIcon ; Vota, Daiana MarinaIcon ; Hauk, Vanesa CintiaIcon ; Gallino, LucilaIcon ; Merech, Fátima IsabelIcon ; Grasso, Esteban NicolasIcon ; Perez Leiros, ClaudiaIcon
Fecha de publicación: 02/2019
Editorial: Wiley
Revista: Annals of the New York Academy of Sciences
ISSN: 0077-8923
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

A network of cell–cell communications through contact and soluble factors supports the maternal–placental interaction and provides a suitable environment for fetal growth. Trophoblast cells take center stage at these loops: they interact with maternal leukocytes to sustain the varying demands of gestation, and they synthesize hormones, cytokines among other factors that contribute to the maintenance of immune homeostasis. Here, we discuss vasoactive intestinal peptide (VIP) and its potential as a regulatory neuropeptide in pregnancy. VIP is synthesized by trophoblast cells; it regulates trophoblast cell function and interaction with the major immune cell populations present in the pregnant uterus. VIP activity produces an anti-inflammatory microenvironment by modulating the functional profile of monocytes, macrophages, and regulatory T cells. Trophoblast VIP inhibits neutrophil extracellular trap formation and accelerates neutrophil apoptosis, enabling their silent clearance by phagocytic cells. The effects of VIP on the trophoblast–immune interaction are consistent with its regulatory role throughout pregnancy for immune homeostasis maintenance. These observations may provide new clues for pharmacological targeting of pregnancy complications associated with exacerbated inflammation.
Palabras clave: IMMUNE HOMEOSTASIS , PREGNANCY , TROPHOBLAST CELL LINES , VASOACTIVE INTESTINAL POLYPEPTIDE
Ver el registro completo
 
Archivos asociados
Tamaño: 478.7Kb
Formato: PDF
.
Solicitar
Licencia
info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/94084
URL: https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/nyas.13632
DOI: https://doi.org/10.1111/nyas.13632
Colecciones
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Ramhorst, Rosanna Elizabeth; Calo, Guillermina; Paparini, Daniel Esteban; Vota, Daiana Marina; Hauk, Vanesa Cintia; et al.; Control of the inflammatory response during pregnancy: Potential role of VIP as a regulatory peptide; Wiley; Annals of the New York Academy of Sciences; 1437; 1; 2-2019; 15-21
Compartir
Altmétricas
 

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • X Conicet Digital
  • Instagram
  • YouTube
  • Sound Cloud
  • LinkedIn

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES