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dc.contributor.author
González Vicente, Agustín
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dc.contributor.author
Hong, Nancy J.
dc.contributor.author
Yang, Nianxin
dc.contributor.author
Cabral, Pablo D.
dc.contributor.author
Berthiaume, Jessica M.
dc.contributor.author
Dominici, Fernando Pablo
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dc.contributor.author
Garvin, Jeffrey L.
dc.date.available
2020-01-08T18:39:00Z
dc.date.issued
2018-09
dc.identifier.citation
González Vicente, Agustín; Hong, Nancy J.; Yang, Nianxin; Cabral, Pablo D.; Berthiaume, Jessica M.; et al.; Dietary Fructose Increases the Sensitivity of Proximal Tubules to Angiotensin II in Rats Fed High-Salt Diets; Multidisciplinary Digital Publishing Institute; Nutrients; 9-2018
dc.identifier.issn
2072-6643
dc.identifier.uri
http://hdl.handle.net/11336/93978
dc.description.abstract
Dietary fructose causes salt-sensitive hypertension. Proximal tubules (PTs) reabsorb 70% of the filtered NaCl. Angiotensin II (Ang II), atrial natriuretic peptide (ANP) and norepinephrine (NE) regulate this process. Although Ang II signaling blockade ameliorates fructose-induced salt-sensitive hypertension, basal PT Na+ reabsorption and its sensitivity to the aforementioned factors have not been studied in this model. We hypothesized consuming fructose with a high-salt diet selectively enhances the sensitivity of PT transport to Ang II. We investigated the effects of Ang II, ANP and NE on PT Na reabsorption in rats fed a high-salt diet drinking tap water (HS) or 20% fructose (HS-FRU). Oxygen consumption (QO2) was used as a measure of all ATP-dependent transport processes. Na+/K+-ATPase and Na+/H+-exchange (NHE) activities were studied because they represent primary apical and basolateral transporters in this segment. The effect of 10−12 mol/L Ang II in QO2 by PTs from HS-FRU was larger than HS (p < 0.02; n = 7). In PTs from HS-FRU 10−12 mol/L Ang II stimulated NHE activity by 2.6 ± 0.7 arbitrary fluorescence units/s (p < 0.01; n = 5) but not in those from HS. The stimulatory effect of Ang II on PT Na+/K+-ATPase activity was not affected by HS-FRU. Responses of QO2 and NHE activity to ANP did not differ between groups. The response of QO2 to NE was unaltered by HS-FRU. We concluded that the sensitivity of PT Na+ reabsorption specifically to Ang II is enhanced by HS-FRU. This maintains high rates of transport even in the presence of low concentrations of the peptide, and likely contributes to the hypertension.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Multidisciplinary Digital Publishing Institute
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANGIOTENSIN
dc.subject
FRUCTOSE
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Na+/K+-ATPase
dc.subject
SODIUM EXCRETION
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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dc.title
Dietary Fructose Increases the Sensitivity of Proximal Tubules to Angiotensin II in Rats Fed High-Salt Diets
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-21T19:01:41Z
dc.journal.pais
Suiza
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dc.description.fil
Fil: González Vicente, Agustín. Case Western Reserve University; Estados Unidos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Hong, Nancy J.. Case Western Reserve University; Estados Unidos
dc.description.fil
Fil: Yang, Nianxin. Case Western Reserve University; Estados Unidos
dc.description.fil
Fil: Cabral, Pablo D.. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Merk Research Laboratories; Estados Unidos. Case Western Reserve University; Estados Unidos
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Fil: Berthiaume, Jessica M.. Case Western Reserve University; Estados Unidos
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Fil: Dominici, Fernando Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Garvin, Jeffrey L.. Case Western Reserve University; Estados Unidos
dc.journal.title
Nutrients
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6643/10/9/1244
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.3390/nu10091244
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