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dc.contributor.author
Hedin, Marshal
dc.contributor.author
Derkarabetian, Shahan
dc.contributor.author
Ramirez, Martin Javier
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dc.contributor.author
Vink, Cor
dc.contributor.author
Bond, Jason E.
dc.date.available
2020-01-08T16:37:00Z
dc.date.issued
2018-12
dc.identifier.citation
Hedin, Marshal; Derkarabetian, Shahan; Ramirez, Martin Javier; Vink, Cor; Bond, Jason E.; Phylogenomic reclassification of the world's most venomous spiders (Mygalomorphae, Atracinae), with implications for venom evolution; Nature Publishing Group; Scientific Reports; 8; 1; 12-2018; 1-7
dc.identifier.issn
2045-2322
dc.identifier.uri
http://hdl.handle.net/11336/93957
dc.description.abstract
Here we show that the most venomous spiders in the world are phylogenetically misplaced. Australian atracine spiders (family Hexathelidae), including the notorious Sydney funnel-web spider Atrax robustus, produce venom peptides that can kill people. Intriguingly, eastern Australian mouse spiders (family Actinopodidae) are also medically dangerous, possessing venom peptides strikingly similar to Atrax hexatoxins. Based on the standing morphology-based classification, mouse spiders are hypothesized distant relatives of atracines, having diverged over 200 million years ago. Using sequence-capture phylogenomics, we instead show convincingly that hexathelids are non-monophyletic, and that atracines are sister to actinopodids. Three new mygalomorph lineages are elevated to the family level, and a revised circumscription of Hexathelidae is presented. Re-writing this phylogenetic story has major implications for how we study venom evolution in these spiders, and potentially genuine consequences for antivenom development and bite treatment research. More generally, our research provides a textbook example of the applied importance of modern phylogenomic research.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Sydney funnel-web spider
dc.subject
Atrax
dc.subject
Hexathelidae
dc.subject
hexatoxins
dc.subject.classification
Biología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Phylogenomic reclassification of the world's most venomous spiders (Mygalomorphae, Atracinae), with implications for venom evolution
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-16T19:30:07Z
dc.journal.volume
8
dc.journal.number
1
dc.journal.pagination
1-7
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Hedin, Marshal. San Diego State University; Estados Unidos
dc.description.fil
Fil: Derkarabetian, Shahan. University of California; Estados Unidos. San Diego State University; Estados Unidos
dc.description.fil
Fil: Ramirez, Martin Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; Argentina
dc.description.fil
Fil: Vink, Cor. Canterbury Museum Christchurch; Nueva Zelanda
dc.description.fil
Fil: Bond, Jason E.. Auburn University; Estados Unidos
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-018-19946-2
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-018-19946-2
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