Identification of driver and subclonal mutations in ASXL1 and IDH1/IDH2 genes in an Argentine series of patients with myelofibrosis

Myelofibrosis (MF) is a Philadelphia-negative myeloproliferative neoplasm (MPN) characterized by clonal proliferation of hematopoietic stem cells, progressive bone marrow fibrosis, abnormal cytokine expression, anemia, splenomegaly, extramedullary hematopoiesis, constitutional symptoms, cachexia, leukemic progression, and shortened survival.1 MF can be diagnosed as a primary myelofibrosis (PMF) disorder or as a complication of the evolution of polycythemia vera (MF post-PV) or essential thrombocythemia (MF post-ET)...

Palabras clave: Myelofibrosis , ASXL1 , IDH1/IDH2 , Driver Mutations

Ver el registro completo

Archivos asociados

Tamaño: 597.4Kb

Formato: PDF

Descargar

Licencia

Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/93930

DOI: https://doi.org/10.1111/ijlh.12847

URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/ijlh.12847

Colecciones

Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL

Citación

Scheps, Karen; Meyer, C.; Bestach, Yesica Soledad; Enrico, A.; Bengio, Ruben Guillermo; et al.; Identification of driver and subclonal mutations in ASXL1 and IDH1/IDH2 genes in an Argentine series of patients with myelofibrosis; Wiley Blackwell Publishing, Inc; International Journal of Laboratory Hematology; 40; 4; 8-2018; e82-e86

Altmétricas