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dc.contributor.author
Ferreiro, Diego
dc.contributor.author
Komives, Elizabeth A.
dc.contributor.author
Wolynes, Peter G.
dc.date.available
2020-01-07T19:01:40Z
dc.date.issued
2018-02-05
dc.identifier.citation
Ferreiro, Diego; Komives, Elizabeth A.; Wolynes, Peter G.; Frustration, function and folding; Current Biology; Current Opinion In Structural Biology; 48; 5-2-2018; 68-73
dc.identifier.issn
0959-440X
dc.identifier.uri
http://hdl.handle.net/11336/93870
dc.description.abstract
Natural protein molecules are exceptional polymers. Encoded in apparently random strings of amino-acids, these objects perform clear physical tasks that are rare to find by simple chance. Accurate folding, specific binding, powerful catalysis, are examples of basic chemical activities that the great majority of polypeptides do not display, and are thought to be the outcome of the natural history of proteins. Function, a concept genuine to Biology, is at the core of evolution and often conflicts with the physical constraints. Locating the frustration between discrepant goals in a recurrent system leads to fundamental insights about the chances and necessities that shape the encoding of biological information.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Current Biology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Protein folding
dc.subject
Protein function
dc.subject.classification
Otras Ciencias Naturales y Exactas
dc.subject.classification
Otras Ciencias Naturales y Exactas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Frustration, function and folding
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-21T19:46:48Z
dc.journal.volume
48
dc.journal.pagination
68-73
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Ferreiro, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Komives, Elizabeth A.. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Wolynes, Peter G.. Rice University; Estados Unidos
dc.journal.title
Current Opinion In Structural Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.sbi.2017.09.006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0959440X17300726
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005193/
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