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dc.contributor.author
Jeong, Yeon-Tae  
dc.contributor.author
Simoneschi, Daniele  
dc.contributor.author
Keegan, Sarah  
dc.contributor.author
Melville, David  
dc.contributor.author
Adler, Natalia Sol  
dc.contributor.author
Saraf, Anita  
dc.contributor.author
Florens, Laurence  
dc.contributor.author
Washburn, Michael P.  
dc.contributor.author
Cavasotto, Claudio Norberto  
dc.contributor.author
Fenyö, David  
dc.contributor.author
Sanchez Cuervo, Ana Maria  
dc.contributor.author
Rossi, Mario  
dc.contributor.author
Pagano, Michele  
dc.date.available
2020-01-07T18:38:48Z  
dc.date.issued
2018-12  
dc.identifier.citation
Jeong, Yeon-Tae; Simoneschi, Daniele; Keegan, Sarah; Melville, David; Adler, Natalia Sol; et al.; The ULK1-FBXW5-SEC23B nexus controls autophagy; eLife Sciences Publications; eLife; 7; 12-2018; 42253-42253  
dc.identifier.issn
2050-084X  
dc.identifier.uri
http://hdl.handle.net/11336/93851  
dc.description.abstract
In response to nutrient deprivation, the cell mobilizes an extensive amount of membrane to form and grow the autophagosome, allowing the progression of autophagy. By providing membranes and stimulating LC3 lipidation, COPII (Coat Protein Complex II) promotes autophagosome biogenesis. Here, we show that the F-box protein FBXW5 targets SEC23B, a component of COPII, for proteasomal degradation and that this event limits the autophagic flux in the presence of nutrients. In response to starvation, ULK1 phosphorylates SEC23B on Serine 186, preventing the interaction of SEC23B with FBXW5 and, therefore, inhibiting SEC23B degradation. Phosphorylated and stabilized SEC23B associates with SEC24A and SEC24B, but not SEC24C and SEC24D, and they re-localize to the ER-Golgi intermediate compartment, promoting autophagic flux. We propose that, in the presence of nutrients, FBXW5 limits COPII-mediated autophagosome biogenesis. Inhibition of this event by ULK1 ensures efficient execution of the autophagic cascade in response to nutrient starvation.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
eLife Sciences Publications  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CRLS  
dc.subject
SCF  
dc.subject
ULK1  
dc.subject
AUTOPHAGY  
dc.subject
CANCER  
dc.subject
CELL  
dc.subject
CELL BIOLOGY  
dc.subject
HUMAN  
dc.subject
UBIQUITIN  
dc.subject.classification
Biología Celular, Microbiología  
dc.subject.classification
Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
The ULK1-FBXW5-SEC23B nexus controls autophagy  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-10-17T14:58:43Z  
dc.journal.volume
7  
dc.journal.pagination
42253-42253  
dc.journal.pais
Países Bajos  
dc.description.fil
Fil: Jeong, Yeon-Tae. Nyu School Of Medicine;  
dc.description.fil
Fil: Simoneschi, Daniele. Nyu School Of Medicine;  
dc.description.fil
Fil: Keegan, Sarah. Nyu School Of Medicine;  
dc.description.fil
Fil: Melville, David. University of California at Berkeley; Estados Unidos  
dc.description.fil
Fil: Adler, Natalia Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Saraf, Anita. Universidad Austral; Argentina  
dc.description.fil
Fil: Florens, Laurence. Stowers Institute For Medical Research;  
dc.description.fil
Fil: Washburn, Michael P.. Stowers Institute For Medical Research;  
dc.description.fil
Fil: Cavasotto, Claudio Norberto. University Of Kansas Medical Center;  
dc.description.fil
Fil: Fenyö, David. Stowers Institute For Medical Research;  
dc.description.fil
Fil: Cuervo, Ana-Maria. Universidad Austral; Argentina  
dc.description.fil
Fil: Rossi, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Pagano, Michele. Nyu School Of Medicine;  
dc.journal.title
eLife  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/42253  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.7554/eLife.42253