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dc.contributor.author
Jeong, Yeon-Tae
dc.contributor.author
Simoneschi, Daniele
dc.contributor.author
Keegan, Sarah
dc.contributor.author
Melville, David
dc.contributor.author
Adler, Natalia Sol
dc.contributor.author
Saraf, Anita
dc.contributor.author
Florens, Laurence
dc.contributor.author
Washburn, Michael P.
dc.contributor.author
Cavasotto, Claudio Norberto
dc.contributor.author
Fenyö, David
dc.contributor.author
Sanchez Cuervo, Ana Maria
dc.contributor.author
Rossi, Mario
dc.contributor.author
Pagano, Michele
dc.date.available
2020-01-07T18:38:48Z
dc.date.issued
2018-12
dc.identifier.citation
Jeong, Yeon-Tae; Simoneschi, Daniele; Keegan, Sarah; Melville, David; Adler, Natalia Sol; et al.; The ULK1-FBXW5-SEC23B nexus controls autophagy; eLife Sciences Publications; eLife; 7; 12-2018; 42253-42253
dc.identifier.issn
2050-084X
dc.identifier.uri
http://hdl.handle.net/11336/93851
dc.description.abstract
In response to nutrient deprivation, the cell mobilizes an extensive amount of membrane to form and grow the autophagosome, allowing the progression of autophagy. By providing membranes and stimulating LC3 lipidation, COPII (Coat Protein Complex II) promotes autophagosome biogenesis. Here, we show that the F-box protein FBXW5 targets SEC23B, a component of COPII, for proteasomal degradation and that this event limits the autophagic flux in the presence of nutrients. In response to starvation, ULK1 phosphorylates SEC23B on Serine 186, preventing the interaction of SEC23B with FBXW5 and, therefore, inhibiting SEC23B degradation. Phosphorylated and stabilized SEC23B associates with SEC24A and SEC24B, but not SEC24C and SEC24D, and they re-localize to the ER-Golgi intermediate compartment, promoting autophagic flux. We propose that, in the presence of nutrients, FBXW5 limits COPII-mediated autophagosome biogenesis. Inhibition of this event by ULK1 ensures efficient execution of the autophagic cascade in response to nutrient starvation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
eLife Sciences Publications
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CRLS
dc.subject
SCF
dc.subject
ULK1
dc.subject
AUTOPHAGY
dc.subject
CANCER
dc.subject
CELL
dc.subject
CELL BIOLOGY
dc.subject
HUMAN
dc.subject
UBIQUITIN
dc.subject.classification
Biología Celular, Microbiología
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
The ULK1-FBXW5-SEC23B nexus controls autophagy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-17T14:58:43Z
dc.journal.volume
7
dc.journal.pagination
42253-42253
dc.journal.pais
Países Bajos
dc.description.fil
Fil: Jeong, Yeon-Tae. Nyu School Of Medicine;
dc.description.fil
Fil: Simoneschi, Daniele. Nyu School Of Medicine;
dc.description.fil
Fil: Keegan, Sarah. Nyu School Of Medicine;
dc.description.fil
Fil: Melville, David. University of California at Berkeley; Estados Unidos
dc.description.fil
Fil: Adler, Natalia Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Saraf, Anita. Universidad Austral; Argentina
dc.description.fil
Fil: Florens, Laurence. Stowers Institute For Medical Research;
dc.description.fil
Fil: Washburn, Michael P.. Stowers Institute For Medical Research;
dc.description.fil
Fil: Cavasotto, Claudio Norberto. University Of Kansas Medical Center;
dc.description.fil
Fil: Fenyö, David. Stowers Institute For Medical Research;
dc.description.fil
Fil: Cuervo, Ana-Maria. Universidad Austral; Argentina
dc.description.fil
Fil: Rossi, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Pagano, Michele. Nyu School Of Medicine;
dc.journal.title
eLife
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/42253
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.7554/eLife.42253
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