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dc.contributor.author
Naftelberg, Shiran
dc.contributor.author
Schor, Ignacio Esteban
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Ast, Gil
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Kornblihtt, Alberto Rodolfo
dc.date.available
2020-01-07T18:35:51Z
dc.date.issued
2015-06
dc.identifier.citation
Naftelberg, Shiran; Schor, Ignacio Esteban; Ast, Gil; Kornblihtt, Alberto Rodolfo; Regulation of alternative splicing through coupling with transcription and chromatin structure; Annual Reviews; Annual Review Of Biochemistry; 84; 6-2015; 165-198
dc.identifier.issn
0066-4154
dc.identifier.uri
http://hdl.handle.net/11336/93849
dc.description.abstract
Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of genetic information from DNA to proteins by expanding the coding capacity of genomes. Regulation of alternative splicing is as important as regulation of transcription to determine cell- and tissue-specific features, normal cell functioning, and responses of eukaryotic cells to external cues. Its importance is confirmed by the evolutionary conservation and diversification of alternative splicing and the fact that its deregulation causes hereditary disease and cancer. This review discusses the multiple layers of cotranscriptional regulation of alternative splicing in which chromatin structure, DNA methylation, histone marks, and nucleosome positioning play a fundamental role in providing a dynamic scaffold for interactions between the splicing and transcription machineries. We focus on evidence for how the kinetics of RNA polymerase II (RNAPII) elongation and the recruitment of splicing factors and adaptor proteins to chromatin components act in coordination to regulate alternative splicing.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Annual Reviews
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALTERNATIVE SPLICING
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CHROMATIN ORGANIZATION
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HISTONE MODIFICATIONS
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MOLECULAR EVOLUTION
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NUCLEOSOME POSITIONING
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TRANSCRIPTION
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Regulation of alternative splicing through coupling with transcription and chromatin structure
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-09-30T18:50:55Z
dc.journal.volume
84
dc.journal.pagination
165-198
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Palo Alto
dc.description.fil
Fil: Naftelberg S. Sackler Medical School - Tel Aviv University; Israel
dc.description.fil
Fil: Schor, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Ast, Gil. Sackler Medical School, Tel Aviv; Israel
dc.description.fil
Fil: Kornblihtt, Alberto Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.journal.title
Annual Review Of Biochemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.annualreviews.org/doi/abs/10.1146/annurev-biochem-060614-034242
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1146/annurev-biochem-060614-034242
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