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dc.contributor.author
Medelnik, Jan Philip
dc.contributor.author
Roensch, Kathleen
dc.contributor.author
Okawa, Satoshi
dc.contributor.author
del Sol, Antonio
dc.contributor.author
Chara, Osvaldo
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dc.contributor.author
Mchedlishvili, Levan
dc.contributor.author
Tanaka, Elly M.
dc.date.available
2020-01-07T17:45:19Z
dc.date.issued
2018-06
dc.identifier.citation
Medelnik, Jan Philip; Roensch, Kathleen; Okawa, Satoshi; del Sol, Antonio; Chara, Osvaldo; et al.; Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells; Cell Press; Stem Cell Reports; 10; 6; 6-2018; 1751-1765
dc.identifier.issn
2213-6711
dc.identifier.uri
http://hdl.handle.net/11336/93820
dc.description.abstract
In the developing nervous system, neural stem cells are polarized and maintain an apical domain facing a central lumen. The presence of apical membrane is thought to have a profound influence on maintaining the stem cell state. With the onset of neurogenesis, cells lose their polarization, and the concomitant loss of the apical domain coincides with a loss of the stem cell identity. Little is known about the molecular signals controlling apical membrane size. Here, we use two neuroepithelial cell systems, one derived from regenerating axolotl spinal cord and the other from human embryonic stem cells, to identify a molecular signaling pathway initiated by lysophosphatidic acid that controls apical membrane size and consequently controls and maintains epithelial organization and lumen size in neuroepithelial rosettes. This apical domain size increase occurs independently of effects on proliferation and involves a serum response factor-dependent transcriptional induction of junctional and apical membrane components. Medelnik and colleagues identify lysophosphatidic acid as a serum factor that has a major effect on the expansion of the apical domain of human ESC-derived neural progenitor cells, resulting in the formation of very large neural rosette-like structures that can be maintained for many passages in the absence of neuronal and glial differentiation if constantly supplied with LPA.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
APICAL DOMAIN
dc.subject
CELL POLARIZATION
dc.subject
HUMAN EMBRYONIC STEM CELLS
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LUMEN FORMATION/ORGANIZATION
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LYSOPHOSPHATIDIC ACID
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NEURAL PROGENITOR CELLS
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NEURAL ROSETTES
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NEURAL STEM CELLS
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NEUROEPITHELIAL CELLS
dc.subject.classification
Biología del Desarrollo
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-17T20:12:21Z
dc.journal.volume
10
dc.journal.number
6
dc.journal.pagination
1751-1765
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Medelnik, Jan Philip. Center For Regenerative Therapies Dresden; . Max Planck Institute Of Molecular Cell Biology And Genetics; . Research Institute Of Molecular Pathology, Vienna; Austria
dc.description.fil
Fil: Roensch, Kathleen. Center For Regenerative Therapies Dresden; . Max Planck Institute Of Molecular Cell Biology And Genetics;
dc.description.fil
Fil: Okawa, Satoshi.
dc.description.fil
Fil: del Sol, Antonio. University Of Luxembourg;
dc.description.fil
Fil: Chara, Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
dc.description.fil
Fil: Mchedlishvili, Levan. Universitätsklinikum Greifswald Der Ernst-moritz-arndt-universität Greifswald; . Max Planck Institute Of Molecular Cell Biology And Genetics; . Center For Regenerative Therapies Dresden;
dc.description.fil
Fil: Tanaka, Elly M.. Center For Regenerative Therapies Dresden; . Max Planck Institute Of Molecular Cell Biology And Genetics; . Research Institute Of Molecular Pathology, Vienna; Austria
dc.journal.title
Stem Cell Reports
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.stemcr.2018.04.018
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2213671118301863
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