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dc.contributor.author
García, María del Carmen
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dc.contributor.author
Adler Graschinsky, Edda
dc.contributor.author
Celuch, Stella Maris
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dc.date.available
2020-01-07T17:05:03Z
dc.date.issued
2003-10
dc.identifier.citation
García, María del Carmen; Adler Graschinsky, Edda; Celuch, Stella Maris; Hypotensive effect of anandamide through the activation of CB1 and VR1 spinal receptors in urethane-anesthetized rats; Springer; Naunyn-schmiedebergs Archives Of Pharmacology; 368; 4; 10-2003; 270-276
dc.identifier.issn
0028-1298
dc.identifier.uri
http://hdl.handle.net/11336/93796
dc.description.abstract
This study examined the effect of intrathecal (i.t.) injection of the endocannabinoid anandamide in urethane-anesthetized rats. The tip of the i.t. cannula was positioned at the T12–L1 level of the spinal cord. Either anandamide or its metabolically stable analogue methanandamide (25 to 100 nmol) produced dose-dependent decreases in the blood pressure that persisted at least for up to 30 min. The hypotensive responses to 100 nmol anandamide and to 100 nmol methanandamide were −17.7±1.6 mmHg (n=5) and −17.9±2.0 mmHg (n=4), respectively. Hypotensive effects were also obtained with the CB1 cannabinoid receptor agonist WIN 55212-2 (20 nmol; i.t.) as well as with the vanilloid VR1 receptor agonist capsaicin (3 nmol; i.t.). Nicotinic ganglionic blockade with hexamethonium bromide [10 mg/kg; intravenous(i.v.)] abolished the responses to both anandamide and capsaicin. The i.t. administration of the CB1 receptor antagonist, 20 nmol SR 141716A, as well as the VR1 receptor antagonist, 20 nmol capsazepine, prevented almost completely the hypotensive responses to both anandamide and methanandamide. SR 141716A prevented the hypotension caused by WIN 55212-2 but did not modify the response to the vanilloid receptor agonist capsaicin. On the contrary, capsazepine antagonized the hypotension caused by capsaicin but failed to affect the decrease in blood pressure caused by the CB1 cannabinoid receptor agonist WIN 55212-2. These results suggest that anandamide could modulate the blood pressure through the activation of cannabinoid CB1 receptors and vanilloid VR1 receptors localized at the spinal cord.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANANDAMIDE
dc.subject
BLOOD PRESSURE
dc.subject
CANNABINOIDS
dc.subject
CB1 RECEPTORS
dc.subject
SPINAL CORD
dc.subject
URETHANE-ANESTHETIZED RATS
dc.subject
VR1 RECEPTORS
dc.subject.classification
Farmacología y Farmacia
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Hypotensive effect of anandamide through the activation of CB1 and VR1 spinal receptors in urethane-anesthetized rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-11-25T17:46:33Z
dc.journal.volume
368
dc.journal.number
4
dc.journal.pagination
270-276
dc.journal.pais
Alemania
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dc.description.fil
Fil: García, María del Carmen. ININFA; Argentina
dc.journal.title
Naunyn-schmiedebergs Archives Of Pharmacology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00210-003-0800-x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00210-003-0800-x
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