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dc.contributor.author
Aguirre, Sebastian
dc.contributor.author
Malirat, Viviana
dc.contributor.author
Scodeller, Eduardo
dc.contributor.author
Mattion, Nora Marta
dc.date.available
2020-01-07T15:28:01Z
dc.date.issued
2011-01
dc.identifier.citation
Aguirre, Sebastian; Malirat, Viviana; Scodeller, Eduardo; Mattion, Nora Marta; First full-length genomic sequence of a hepatitis A virus isolated in Argentina shows recombination between subgenotypes IA and IB; Elsevier Science; Virus Research; 155; 1; 1-2011; 316-324
dc.identifier.issn
0168-1702
dc.identifier.uri
http://hdl.handle.net/11336/93768
dc.description.abstract
A hepatitis A virus (HAV) recovered in Argentina from a stool sample of a sick child in the year 2006 (HAV-Arg/06) was entirely sequenced. Phylogenetic analysis included the HAV-Arg/06 sequence in subgenotype IA, either considering the usual VP1-2A variable junction fragment or the full length nucleotide sequence. Interestingly, a recombination event with subgenotype IB, involving a portion of the 2C-3A nonstructural proteins coding region (nucleotides 4961-5140) was detected using specific software. Only subgenotype IA strains have been detected in Argentina or Uruguay, whereas subgenotype IA and IB strains have been reported to circulate in Brazil. Although recombination has been given an important role in the evolution of picornaviruses, there have been only a few reports of its involvement in the evolution of HAV, probably due to the limited number of complete HAV sequences available. This study constitutes the first report of a full-length HAV sequence in Argentina and the third in South America, after the sequence of the IA isolate HAV5 from Uruguay and the IB isolate HAF-203 from Brazil. The availability of new sequence data covering the complete HAV genome will help establish a more consistent genetic relatedness among HAV isolates and the role of recombination in its evolution.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ARGENTINE ISOLATE
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FULL-LENGTH SEQUENCE
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HEPATITIS A
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RECOMBINATION EVENT
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Virología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
First full-length genomic sequence of a hepatitis A virus isolated in Argentina shows recombination between subgenotypes IA and IB
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-06-10T21:51:02Z
dc.journal.volume
155
dc.journal.number
1
dc.journal.pagination
316-324
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Aguirre Sebastian. Centro de Ciencia y Tecnología Dr. César Milstein; Argentina ; Argentina
dc.description.fil
Fil: Malirat, Viviana. Centro de Ciencia y Tecnología Dr. César Milstein; Argentina
dc.description.fil
Fil: Scodeller, Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Mattion, Nora Marta. Centro de Ciencia y Tecnología Dr. César Milstein; Argentina
dc.journal.title
Virus Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/doi:10.1016/j.virusres.2010.10.030
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0168170210003898
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