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Artículo

Antiproliferative effect and ultrastructural alterations induced by 5-O-methylembelin on Trypanosoma cruzi

Spina Zapata, Renata MaríaIcon ; Lozano, Esteban SebastiánIcon ; Barrera, Patricia AndreaIcon ; Agüero, María BelénIcon ; Tapia, Aníbal Alejandro; Feresin, Gabriela EglyIcon ; Sosa Escudero, Miguel AngelIcon
Fecha de publicación: 07/2018
Editorial: Elsevier Gmbh
Revista: Phytomedicine
ISSN: 0944-7113
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Química Orgánica

Resumen

Background: Embelin (EMB), obtained from Oxalis erythrorhiza Gillies ex Hooker et Arnott (Oxalidaceae), was reported against Trypanosoma cruzi and Leishmania spp. Additionally, antiprotozoan activity against Plasmodium falciparum was reported for its methylated derivative (ME). Purpose: To evaluate the potential anti-Trypanosoma cruzi activity of EMB, ME and 2,5-di-O-methylembelin (DME) and analyze the possible mechanism of action. Study design/Methods: EMB was isolated by a chromatographic method from the air-dried ground whole plant. To evaluate the effects of methylation, ME and DME were synthesized and tested against T. cruzi epimastigotes and trypomastigotes. The most active compound ME was evaluated against amastigotes. Ultrastructural alterations, ROS generation and the effect on mitochondrial activity of ME were measured. Results: Compounds inhibited the proliferation of epimastigotes. ME was also active against intracellular amastigotes. Mitochondrial alterations were observed by TEM. Additionally, ME modified the mitochondrial activity, and induced an increase in ROS levels. These evidences postulate the mitochondrion as a possible target of ME. Conclusion: ME inhibited amastigotes proliferation, thus being a potential lead compound for the treatment of Chagas’ disease.
Palabras clave: 2,5-DI-O-METHYLEMBELIN (DME) , 5-O-METHYLEMBELIN (ME) , CHAGAS' DISEASE , EMBELIN (EMB) , TRYPANOSOMA CRUZI
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/93309
URL: https://www.sciencedirect.com/science/article/pii/S0944711318301326
DOI: https://doi.org/10.1016/j.phymed.2018.04.032
Colecciones
Articulos(CCT - SAN JUAN)
Articulos de CENTRO CIENTIFICO TECNOLOGICO CONICET - SAN JUAN
Articulos(IHEM)
Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS
Citación
Spina Zapata, Renata María; Lozano, Esteban Sebastián; Barrera, Patricia Andrea; Agüero, María Belén; Tapia, Aníbal Alejandro; et al.; Antiproliferative effect and ultrastructural alterations induced by 5-O-methylembelin on Trypanosoma cruzi; Elsevier Gmbh; Phytomedicine; 46; 7-2018; 111-118
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