Artículo
Multilayered electrospun nanofibrous scaffolds for tailored controlled release of embelin
Cortez Tornello, Pablo Roberto
; Feresin, Gabriela Egly
; Tapia, Aníbal Alejandro; Cuadrado, Teresita Raquel
; Abraham, Gustavo Abel
Fecha de publicación:
01/2018
Editorial:
Taylor & Francis
Revista:
Soft Materials
ISSN:
1539-445X
e-ISSN:
1539-4468
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Polymeric electrospun meshes are highly attractive as versatile platforms for numerous biomedical applications, tissue engineering, biosensors, and controlled release of bioactive agents. Herein, we describe the preparation and characterization of multilayered nanofibrous poly(ε-caprolactone) scaffolds with different embelin content by electrospinning technique. In vitro release in physiological and acidic pH and kinetic analysis were performed. The results show that it is possible to modulate the release profile depending on the number and thickness of layers added to drug-loaded scaffold that acts as an embelin reservoir. Electrospun multilayered scaffolds present characteristics, morphology and release profiles that could be very attractive for use as embelin controlled release systems.
Palabras clave:
DRUG RELEASE
,
ELECTROSPINNING
,
EMBELIN
,
MULTILAYERED SCAFFOLDS
,
NANOFIBERS
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Identificadores
Colecciones
Articulos(CCT - SAN JUAN)
Articulos de CENTRO CIENTIFICO TECNOLOGICO CONICET - SAN JUAN
Articulos de CENTRO CIENTIFICO TECNOLOGICO CONICET - SAN JUAN
Articulos(INTEMA)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Citación
Cortez Tornello, Pablo Roberto; Feresin, Gabriela Egly; Tapia, Aníbal Alejandro; Cuadrado, Teresita Raquel; Abraham, Gustavo Abel; Multilayered electrospun nanofibrous scaffolds for tailored controlled release of embelin; Taylor & Francis; Soft Materials; 16; 1; 1-2018; 51-61
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