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Artículo

Novel hydro- and lipo-philic selenium zinc(II) phthalocyanines: Synthesis, photophysical properties and photodynamic effects on CT26 colon carcinoma cells

Ezquerra Riega, Sergio DarioIcon ; Chiarante, Nicolás AgustínIcon ; Valli, FedericoIcon ; Marino, Veronica JulietaIcon ; Roguin, Leonor PatriciaIcon ; Awruch, JosefinaIcon ; Garcia Vior, María CeciliaIcon
Fecha de publicación: 09/2018
Editorial: Elsevier
Revista: Dyes and Pigments
ISSN: 0143-7208
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Química Orgánica; Química Orgánica

Resumen

The synthesis and photochemical properties of two novel selenium zinc(II) phthalocyanines, a lipid-soluble 2,9(10),16(17),23(24)-tetrakis [(2-dimethylamino)ethylselanyl]phthalocyaninato zinc(II) (4) and its water-soluble quaternized derivative 2,9(10),16(17),23(24)-tetrakis [(2- trimethylammonium)ethylselanyl]phthalocyaninato zinc(II) tetraiodide (5), were investigated. Maximum absorption values were 689 nm and 684 nm for 4 and 5 in DMF, respectively. In addition, phthalocyanines were revealed to be very efficient singlet oxygen generators with high values of ΦΔ 0.74 and 0.84 for 4 and 5 in DMF, and they were photostable over the irradiation times studied. The photodynamic effect were evaluated on CT26 colon carcinoma cells. After light exposure, 4 and 5 were found to be cytotoxic, and IC50 values were 0.5 ± 0.1 μM and 2.3 ± 0.6 μM, respectively. The production of a greater amount of reactive oxygen species after phthalocyanines irradiation would be responsible for its potent phototoxic action on CT26 colon carcinoma cells.
Palabras clave: CT26 cells , PHOTODYNAMIC THERAPY , SELENIUM ZINC(II) PHTHALOCYANINES , SINGLET OXYGEN
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/93100
URL: http://linkinghub.elsevier.com/retrieve/pii/S0143720818300822
DOI: http://dx.doi.org/10.1016/j.dyepig.2018.03.067
Colecciones
Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Ezquerra Riega, Sergio Dario; Chiarante, Nicolás Agustín; Valli, Federico; Marino, Veronica Julieta; Roguin, Leonor Patricia; et al.; Novel hydro- and lipo-philic selenium zinc(II) phthalocyanines: Synthesis, photophysical properties and photodynamic effects on CT26 colon carcinoma cells; Elsevier; Dyes and Pigments; 156; 9-2018; 133-139
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