Artículo

Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics

Cardama, Georgina AlexandraIcon ; Alonso, Daniel FernandoIcon ; González, NazarenoIcon ; Maggio, JulianIcon ; Gomez, D.E.; Rolfo, C.; Lorenzano Menna, PabloIcon
Fecha de publicación: 04/2018
Editorial: Elsevier Science Inc
Revista: Critical Reviews In Oncology Hematology
ISSN: 1040-8428
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Rac1 GTPase signaling pathway has a critical role in the regulation of a plethora of cellular functions governing cancer cell behavior. Recently, it has been shown a critical role of Rac1 in the emergence of resistance mechanisms to cancer therapy. This review describes the current knowledge regarding Rac1 pathway deregulation and its association with chemoresistance, radioresistance, resistance to targeted therapies and immune evasion. This supports the idea that interfering Rac1 signaling pathway could be an interesting approach to tackle cancer resistance.
Palabras clave: CHEMORESISTANCE , IMMUNE EVASION , RAC1 INHIBITION , RADIORESISTANCE , TARGETED-THERAPY
 
Archivos asociados
Thumbnail
 
Tamaño: 1.129Mb
Formato: PDF
.
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/92937
URL: http://linkinghub.elsevier.com/retrieve/pii/S104084281730327X
DOI: http://dx.doi.org/10.1016/j.critrevonc.2018.01.012
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Cardama, Georgina Alexandra; Alonso, Daniel Fernando; González, Nazareno; Maggio, Julian; Gomez, D.E.; et al.; Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics; Elsevier Science Inc; Critical Reviews In Oncology Hematology; 124; 4-2018; 29-36
Compartir
Altmétricas