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dc.contributor.author
Tormen, Luciano
dc.contributor.author
Gil, Raul Andres
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dc.contributor.author
Frescura, Vera L.A.
dc.contributor.author
Martinez, Luis Dante
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dc.contributor.author
Curtius, Adilson J.
dc.date.available
2019-12-23T23:50:22Z
dc.date.issued
2010-11-26
dc.identifier.citation
Tormen, Luciano; Gil, Raul Andres; Frescura, Vera L.A.; Martinez, Luis Dante; Curtius, Adilson J.; Determination of trace elements in biological samples treated with formic acid by inductively coupled plasma mass spectrometry using a microconcentric nebulizer; Pergamon-Elsevier Science Ltd; Spectrochimica Acta Part B: Atomic Spectroscopy; 65; 11; 26-11-2010; 959-966
dc.identifier.issn
0584-8547
dc.identifier.uri
http://hdl.handle.net/11336/92873
dc.description.abstract
A simple and fast method for the determination of As, Ba, Cd, Co, Cu, Fe, Ga, Mn, Mo, Ni, Pb, Rb, Se, Sr, Tl, U, V and Zn in biological samples by inductively coupled plasma mass spectrometry (ICP-MS), after sample solubilization with formic acid and introduction by a microconcentric nebulizer, is proposed. The sample is mixed with formic acid, kept at 90 °C for one hour and then diluted with nitric acid aqueous solution to a 50% v/v formic acid and 1% v/v nitric acid final concentrations. The final sample solution flow rate for introduction into the plasma was 30 μL min-1. The optimized and adopted nebulizer gas flow rate was 0.7 L min-1 and RF power was 800 W. These conditions are very different than those normally used when a conventional nebulizer is employed. Rodhium was used as internal standard. External calibration against aqueous standard solutions, without formic acid, could be used for quantification, except for As, Se and Zn. However, external calibration with 50% formic acid allows the determination of all analytes with high accuracy and it is recommended. The detection limits were between 0.0005 (Tl) and 0.22 mg kg-1 (Fe) and the precision expressed by the relative standard deviations (RSD) were between 0.2% (Sr) and 3.5% (Ga). Accuracy was validated by the analysis of four certified reference biological materials of animal tissues, comparing the results by linear regressions and by the t-test at a 95% confidence level. The recommended procedure avoids plasma instability and carbon deposit on the cones.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BIOLOGICAL SAMPLES
dc.subject
FORMIC ACID SOLUBILIZATION
dc.subject
ICP-MS
dc.subject
MICROCONCENTRIC NEBULIZER
dc.subject
TRACE ELEMENTS
dc.subject.classification
Química Analítica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Determination of trace elements in biological samples treated with formic acid by inductively coupled plasma mass spectrometry using a microconcentric nebulizer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-10T19:31:47Z
dc.journal.volume
65
dc.journal.number
11
dc.journal.pagination
959-966
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Luciano Tormen. Departamento de Química, Universidade Federal de Santa Catarina, Depto. Química, Campus Trindade; Brasil
dc.description.fil
Fil: Gil, Raul Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
dc.description.fil
Fil: Vera L.A. Frescura. Departamento de Química, Universidade Federal de Santa Catarina, Depto. Química, Campus Trindade; Brasil
dc.description.fil
Fil: Martinez, Luis Dante. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
dc.description.fil
Fil: Adilson J. Curtius. Departamento de Química, Universidade Federal de Santa Catarina, Depto. Química, Campus Trindade; Brasil
dc.journal.title
Spectrochimica Acta Part B: Atomic Spectroscopy
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.sab.2010.09.007
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0584854710002661
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