A control systems analysis of HIV prevention model using impulsive input

Abstract

We investigate a control systems analysis on HIV infection dynamics with regard to enhancement of theimmune response. The HIV dynamic model is modified to include the pharmacokinetics and pharma-codynamics of antiretroviral HIV drugs, and the intake of drug is considered as impulsive control input.As it is administrated at discrete time instants, we assume that this yields an impulsive control problemfor a nonlinear continuous-time system. Based on this new model, we study clinical experiments aboutantirretoviral treatments via numerical simulation and analyse the experimental results. It is noted thatthis modeling approach can help to provide a theoretical explanation of the clinical results. The analysisresult in the paper could imply that the protocol of the experiment might enhance the immune responseagainst HIV.