Mostrar el registro sencillo del ítem
dc.contributor.author
Siano, Alvaro Sebastían
dc.contributor.author
Gatti, Paula Ines
dc.contributor.author
Imaz, María Susana
dc.contributor.author
Zerbini, Elsa Virginia
dc.contributor.author
Simonetta, Arturo Carlos
dc.contributor.author
Lajmanovich, Rafael Carlos
dc.contributor.author
Tonarelli, Georgina Guadalupe
dc.date.available
2019-12-23T17:48:23Z
dc.date.issued
2014-03
dc.identifier.citation
Siano, Alvaro Sebastían; Gatti, Paula Ines; Imaz, María Susana; Zerbini, Elsa Virginia; Simonetta, Arturo Carlos; et al.; A Comparative Study of the Biological Activity of Skin and Granular Gland Secretions of Leptodactylus latrans and Hypsiboas pulchellus from Argentina; ACG Publications; Records Of Natural Products; 8; 3-2014; 128-135
dc.identifier.issn
1307-6167
dc.identifier.uri
http://hdl.handle.net/11336/92798
dc.description.abstract
The potential of the skin of anuran amphibians as a new source of bioactive peptides was investigated . For this purpose, the study collected data in the mid-eastern region of Argentina. Two anuran amphibian species were studied which belong to the Hylidae and Leptodactylidae families, Leptodatylus latrans (Ll) and Hypsiboas pulchellus (Hp). Two methods for the extraction of bioactive components were compared in their effectiveness: solvent extraction (SE) and transcutaneous amphibian stimulation (TAS). Two different approaches were used to study the extracts: i) the direct analysis of the complete samples by MALDI-TOF-MS, and ii) the characterization of bioactive fractions obtained by HPLC and analyzed by MS. The results show that not only the composition of the samples obtained by SE and TAS is different but also their antimicrobial activity. In this sense, only the extracts obtained from Ll and Hp by SE inhibited the growth of Mycobacterium tuberculosis H37Rv. The inhibitory activity of the extracts against the butyrylcholinesterase enzyme (BChE) was also investigated. Samples of Ll showed low percentages of inhibition whereas in Hp samples, the inhibition was moderate (40 -44%). The results suggest that the inhibitory activity of Hp is related to the presence of low molecular weight compounds.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
ACG Publications
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
amphibians
dc.subject
antimicrobial activity
dc.subject
butyrylcholinesterase inhibition
dc.subject
granular glands
dc.subject.classification
Química Orgánica
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
A Comparative Study of the Biological Activity of Skin and Granular Gland Secretions of Leptodactylus latrans and Hypsiboas pulchellus from Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-12-20T21:11:49Z
dc.journal.volume
8
dc.journal.pagination
128-135
dc.journal.pais
Turquía
dc.journal.ciudad
Turquia
dc.description.fil
Fil: Siano, Alvaro Sebastían. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química Organica. Laboratorio de Peptidos Bioactivos; Argentina
dc.description.fil
Fil: Gatti, Paula Ines. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química Organica; Argentina
dc.description.fil
Fil: Imaz, María Susana. Instituto Nacional de Enfermedades Respiratorias Dr. Emilio Coni; Argentina
dc.description.fil
Fil: Zerbini, Elsa Virginia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química Organica; Argentina
dc.description.fil
Fil: Simonetta, Arturo Carlos. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Lajmanovich, Rafael Carlos. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Tonarelli, Georgina Guadalupe. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química Organica. Laboratorio de Peptidos Bioactivos; Argentina
dc.journal.title
Records Of Natural Products
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.acgpubs.org/RNP/2014/Volume8/Issue%201/18-RNP-1211-192.pdf
Archivos asociados