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dc.contributor.author
Siano, Alvaro Sebastían  
dc.contributor.author
Gatti, Paula Ines  
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Imaz, María Susana  
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Zerbini, Elsa Virginia  
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Simonetta, Arturo Carlos  
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Lajmanovich, Rafael Carlos  
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Tonarelli, Georgina Guadalupe  
dc.date.available
2019-12-23T17:48:23Z  
dc.date.issued
2014-03  
dc.identifier.citation
Siano, Alvaro Sebastían; Gatti, Paula Ines; Imaz, María Susana; Zerbini, Elsa Virginia; Simonetta, Arturo Carlos; et al.; A Comparative Study of the Biological Activity of Skin and Granular Gland Secretions of Leptodactylus latrans and Hypsiboas pulchellus from Argentina; ACG Publications; Records Of Natural Products; 8; 3-2014; 128-135  
dc.identifier.issn
1307-6167  
dc.identifier.uri
http://hdl.handle.net/11336/92798  
dc.description.abstract
The potential of the skin of anuran amphibians as a new source of bioactive peptides was investigated . For this purpose, the study collected data in the mid-eastern region of Argentina. Two anuran amphibian species were studied which belong to the Hylidae and Leptodactylidae families, Leptodatylus latrans (Ll) and Hypsiboas pulchellus (Hp). Two methods for the extraction of bioactive components were compared in their effectiveness: solvent extraction (SE) and transcutaneous amphibian stimulation (TAS). Two different approaches were used to study the extracts: i) the direct analysis of the complete samples by MALDI-TOF-MS, and ii) the characterization of bioactive fractions obtained by HPLC and analyzed by MS. The results show that not only the composition of the samples obtained by SE and TAS is different but also their antimicrobial activity. In this sense, only the extracts obtained from Ll and Hp by SE inhibited the growth of Mycobacterium tuberculosis H37Rv. The inhibitory activity of the extracts against the butyrylcholinesterase enzyme (BChE) was also investigated. Samples of Ll showed low percentages of inhibition whereas in Hp samples, the inhibition was moderate (40 -44%). The results suggest that the inhibitory activity of Hp is related to the presence of low molecular weight compounds.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
ACG Publications  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
amphibians  
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antimicrobial activity  
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butyrylcholinesterase inhibition  
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granular glands  
dc.subject.classification
Química Orgánica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
A Comparative Study of the Biological Activity of Skin and Granular Gland Secretions of Leptodactylus latrans and Hypsiboas pulchellus from Argentina  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-12-20T21:11:49Z  
dc.journal.volume
8  
dc.journal.pagination
128-135  
dc.journal.pais
Turquía  
dc.journal.ciudad
Turquia  
dc.description.fil
Fil: Siano, Alvaro Sebastían. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química Organica. Laboratorio de Peptidos Bioactivos; Argentina  
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Fil: Gatti, Paula Ines. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química Organica; Argentina  
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Fil: Imaz, María Susana. Instituto Nacional de Enfermedades Respiratorias Dr. Emilio Coni; Argentina  
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Fil: Zerbini, Elsa Virginia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química Organica; Argentina  
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Fil: Simonetta, Arturo Carlos. Universidad Nacional del Litoral; Argentina  
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Fil: Lajmanovich, Rafael Carlos. Universidad Nacional del Litoral; Argentina  
dc.description.fil
Fil: Tonarelli, Georgina Guadalupe. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química Organica. Laboratorio de Peptidos Bioactivos; Argentina  
dc.journal.title
Records Of Natural Products  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.acgpubs.org/RNP/2014/Volume8/Issue%201/18-RNP-1211-192.pdf