Artículo
Mathematical Modeling of HIV Dynamics After Antiretroviral Therapy Initiation: A Review
Rivadeneira Paz, Pablo Santiago
; Moog, Claude H.; Stan, Guy Bart; Brunet, Cecile; Raffi, Francois; Ferre, Virginie; Costanza, Vicente
; Mhawej, Marie; Biafore, Federico Leonardo
; Ouattara, Djomangan; Ernst, Damien; Fonteneau, Raphael; Xia, Xiaohua
Fecha de publicación:
10/2014
Editorial:
Mary Ann Liebert Inc
Revista:
BioResearch Open Access
ISSN:
2164-7860
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
This review shows the potential ground-breaking impact that mathematical tools may have in the analysis and the understanding of the HIV dynamics. In the first part, early diagnosis of immunological failure is inferred from the estimation of certain parameters of a mathematical model of the HIV infection dynamics. This method is supported by clinical research results from an original clinical trial: data just after 1 month following therapy initiation are used to carry out the model identification. The diagnosis is shown to be consistent with results from monitoring of the patients after 6 months. In the second part of this review, prospective research results are given for the design of individual anti-HIV treatments optimizing the recovery of the immune system and minimizing side effects. In this respect, two methods are discussed. The first one combines HIV population dynamics with pharmacokinetics and pharmacodynamics models to generate drug treatments using impulsive control systems. The second one is based on optimal control theory and uses a recently published differential equation to model the side effects produced by highly active antiretroviral therapy therapies. The main advantage of these revisited methods is that the drug treatment is computed directly in amounts of drugs, which is easier to interpret by physicians and patients
Palabras clave:
Hiv
,
Side-Effects
,
Optimal Control
,
Apoptosis
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Articulos(INTEC)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Citación
Rivadeneira Paz, Pablo Santiago; Moog, Claude H.; Stan, Guy Bart; Brunet, Cecile; Raffi, Francois; et al.; Mathematical Modeling of HIV Dynamics After Antiretroviral Therapy Initiation: A Review; Mary Ann Liebert Inc; BioResearch Open Access; 3; 5; 10-2014; 1-9
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