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dc.contributor.author
Brito Zeron, Pilar
dc.contributor.author
Retamozo, Maria Soledad
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dc.contributor.author
Ramos-Casals Manuel
dc.date.available
2019-12-17T13:38:56Z
dc.date.issued
2018-09
dc.identifier.citation
Brito Zeron, Pilar; Retamozo, Maria Soledad; Ramos-Casals Manuel; Phenotyping Sjögren's syndrome: towards a personalised management of the disease; Clinical & Exper Rheumatology; Clinical And Experimental Rheumatology; 112; 3; 9-2018; 198-209
dc.identifier.issn
0392-856X
dc.identifier.uri
http://hdl.handle.net/11336/92348
dc.description.abstract
Sjögren´s syndrome (SS) is a systemic autoimmune disease that mainly targets the exocrine glands. The disease overwhelmingly affects women around 30-60 years old, and more than 95% of patients present with oral and/or ocular dryness, although they may also develop a wide number of organ-specific systemic manifestations. The variable presentation is often linked to the influence of multiple personal determinants. In this review, we analyse the main geoepidemiological, immunological and histopathological determinants involved in the phenotypic expression of SS. With respect to sicca involvement, some patients (Asian, young-onset diagnosis, males and Ro-carriers) present with a less pronounced involvement in contrast to others with more pronounced dryness (seronegative, isolated La-carriers). With respect to the risk of developing systemic disease/poor outcomes, we propose a phenotypic-driven prognostic classification into patients at low risk (elderly-onset diagnosis, seronegative, isolated La-carriers), moderate risk (Black/African-american, young-onset diagnosis, Ro-carriers) and high risk (males, high focus score or presence of germinal centers in histopathological studies, RF-carriers, cryoglobulinaemic and hypocomplementaemic patients). Phenotype-based clustering of systemic autoimmune diseases may help physicians to offer a more personalised, cost-effective medical care of patients affected by these complex chronic diseases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Clinical & Exper Rheumatology
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Phenotyping
dc.subject
Sjögren's syndrome
dc.subject.classification
Reumatología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Phenotyping Sjögren's syndrome: towards a personalised management of the disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-22T16:40:55Z
dc.journal.volume
112
dc.journal.number
3
dc.journal.pagination
198-209
dc.journal.pais
Italia
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dc.journal.ciudad
Pisa
dc.description.fil
Fil: Brito Zeron, Pilar. Lab Enf Autoinmunes Josep Font, Cellex, Idibaps; España. Hospital Cima-sanitas, Barcelona; España. Department Of Autoimmune Diseases, Hospital Clinic; España. Sjögren Syndrome Research Group (agaur); España
dc.description.fil
Fil: Retamozo, Maria Soledad. Department Of Autoimmune Diseases, Hospital Clinic; España. Instituto Universitario de Ciencias Biomédicas de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Lab Enf Autoinmunes Josep Font, Cellex, Idibaps; España. Sjögren Syndrome Research Group (agaur); España
dc.description.fil
Fil: Ramos-Casals Manuel. Universidad de Barcelona; España. Department Of Autoimmune Diseases, Hospital Clinic; España. Sjögren Syndrome Research Group (agaur); España. Lab Enf Autoinmunes Josep Font, Cellex, Idibaps; España
dc.journal.title
Clinical And Experimental Rheumatology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/30156544
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