Artículo
Pigment epithelium derived factor (PEDF) expression in the male tract of Wistar rats
Conte, María Inés
; Cabrillana, María Eugenia
; Saez Lancellotti, Tania Emilce Estefania
; Simón, Layla Yamila
; Funes, Abi Karenina
; Cayado Gutiérrez, Niubys de Los Milagros
; Tagle-Delgado, Matias Gustavo; Vincenti, Amanda Edith
; Lopez, María Elis; Pietrobon, Elisa Olivia
; Fornes, Miguel Walter
; Monclus, Maria de Los Angeles
Fecha de publicación:
09/2018
Editorial:
Academic Press Inc Elsevier Science
Revista:
Biochemical and Biophysical Research Communications
ISSN:
0006-291X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Pigment epithelium derived factor (PEDF) expression has been described in many organs as showing neurotrophic, anti-angiogenic, anti-apoptotic, anti-inflammatory, anti-oxidant and pro-cell survival properties. However, references to its activity in the male reproductive system are scarce. We aimed to characterize the expression of PEDF in the male reproductive tract of Wistar rats by using RT-PCR, western blot and immunostaining and also evaluate the effect of flutamide in PEDF expression. We found that PEDF is expressed in the epididymis, prostate and seminal vesicles in Wistar rats, but notably not in the testes. Under the effect of flutamide PEDF expression decreased, recovering by suppressing the antiandrogen. The epididymis is an essential organ in sperm maturation-storages. The role of PEDF in this physiological process has not been fully elucidated yet, but considering that in other systems PEDF has anti-apoptotic, anti-oxidants and pro-cell survival properties, its expression along the epididymis could play a role in the protection of spermatozoa while they are stored.
Palabras clave:
EPIDIDYMIS
,
FLUTAMIDE
,
PEDF
,
SPERM
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IHEM)
Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS
Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS
Articulos(IMBECU)
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Citación
Conte, María Inés; Cabrillana, María Eugenia; Saez Lancellotti, Tania Emilce Estefania; Simón, Layla Yamila; Funes, Abi Karenina; et al.; Pigment epithelium derived factor (PEDF) expression in the male tract of Wistar rats; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 504; 1; 9-2018; 257-262
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